Bitcoin Forum

following

Excellent project with good intentions. Good luck to you guys in development, you are doing the right thing. Thanks

reserved

where are the bounties?

a project with great goals and deserves to be supported. projects that focus new cure research on HIV, cancer and regeneration research like this are very useful for everyone in the future. hopefully, for the progress will be smooth and many people who support this project.

Would be nice to have an exact hour so we won't smash our F5  ;D

Oh yeah I undestand. I asked the BM and he said it should be live in a couple hours :).

Bounty thread now live.

https://bitcointalk.org/index.php?topic=3385669

I thought that it could be useful to post the project FAQ as well.

Token Sale Campaign FAQ

​
Token Sale Campaign FAQ

EDIT.

Correcting this old incorrect information so as to prevent the spread of incorrect information. The ICO was cancelled, the token sale (presale and ICO) never actually took place, and the tokens were airdropped as a free reward to the participants of the bounty campaign https://bitcointalk.org/index.php?topic=3385669
 

Thank you very much for the support :)

I found the project very good. There are many people interested in the project including me.
Egretia

This problem, I mean the development of medicine from AIDS, is engaged in the state. A lot of people in the world. Investors - people are cynical, they need a result as a return on their investments. Is this project going to give it to them?

Please consider that this is not equity so we can't provide something like divideds. What we can provide though is a return that is related to the Token utility.  

EDIT.

Correcting this old incorrect information so as to prevent the spread of incorrect information. The ICO was cancelled, the token sale (presale and ICO) never actually took place, and the tokens were airdropped as a free reward to the participants of the bounty campaign https://bitcointalk.org/index.php?topic=3385669
 

This ICO seems very much interesting. Great concept indeed. Focussing to support AIDS cure research was a brilliant intention. Our 101% support is recommended and definitely worth giving! Such amazing project!

That you very much for your support as well. This is a new way of funding AIDS research. In fact, it can be said that with this project we are also decentralizing the way AIDS research is funded. This project is supported by the collectivity with the aim of solving a global issue for the collectivity. Accordingly, it is possible to support the development of a low cost AIDS cure solution, that would otherwise never see the light of day as it would hurt badly the business of all pharmaceutical corporations selling expensive HIV drugs, which aim to make as much profit as possible off of AIDS.

http://spiderman22.altervista.org/costcomp.JPG


*1)Source; Gebo KA, Fleishman JA, et al. Contemporary costs of HIV healthcare in the HAART era. AIDS. 2010;24:2705-15.
*2)Estimated based on the complexity and costly operations required to produce and administer gene therapy autologous cell products for HIV; Stan R, Zaia JA. Practical considerations in gene therapy for HIV cure. Curr HIV/AIDS Rep. 2014;11:11-9.
*3)Estimated cost of our treatment based on our previous experience in propagating and administering SupT1 cells in humanized mice; Fior, J. SupT1 Cell Infusion as a Possible Cell-Based Therapy for HIV: Results from a Pilot Study in Hu-PBMC BRGS Mice. Vaccines. 2016, 4:13.


As you can see our competitors in the industry aim to develop incredibly expensive HIV gene based treatments that will only be affordable by the richest part of the global population. By contrast, we belive that a real cure is something that should be affordable even in low income countries. Because although we are a for profit company, we also have a coscience. And thanks to your support and our work, developing a low cost AIDS cure solution could finally be something possible.

the explanation is very detailed and obviously, I am sure for the participants will easily understand it once and I support this project in order to be successful because it has a purpose that is very noble.

if the explanation of this project is clear certainly will many understand and I am also sure will be many participants and investors who join, and this project will be successful.

it is true that with a clear explanation that it will attract many interested participants and investors, I am also sure this project will achieve its success with maximum later.

with the concept and also the goal is extremely attractive and noble I am convinced that this project will get plenty of support from participants. hopefully later made the projects can be smoothly and successfully.

nice project. I hope many buy tokens

interesting project

much support was very important for the progress of the project, but I also hope that all teams will manage this project very seriously so that the project can be successful.

projects that have a good purpose and are very useful for everyone in the future. hopefully, the progress will be smooth and many investors support this project.

Dev give me reason why just 3 people in behind this project and can we see sosial media link this team?

personally, I very much hope that the project could be developed and a great success. because the project has a goal that is very useful, hopefully this project not only got a lot of support from the participants but hopefully the project can earn extraordinary support from investors.

this project is really good and will be useful to many people in the world. but it needs a lot of funds for development. I hope many investors will be interested to participate in this project.

I agree with you, it is true this project has a very good purpose, besides the support hope his team will also be more eager to work for this project, if support is much but the team is not compact I think this project also will not run, so there must be both,  support and teamwork, success for the future.

Thank you very much for the kind words.

Tell me, do you negotiate with cryptocurrency exchanges about listing your token? If conducted, with what exchanges?
egretia

Well, they should be immediately tradable on Etherdelta. You just have to add our Token as custom Token, and that's it (but it should be officially listed soon). Then, depending on trading volume, we will negotiate to have it listed on bigger exchanges. We will make a specific announcement about listing.

good projects are very exciting awaiting good news from the luck of this promising project
egretia

Thank you very much for your interest. Will keep you updated about any relevant news  :)

We are still waiting for the promised flight test! Tell me when it is scheduled and where? I want to see this performance.
egretia

Thank you very much for the support. This project has the goal to develop novel AIDS cure research as well as a revolutionary blockchain implementation for biomedical research.

ico review
https://icoshrimp.com/innovative-biosearch-brings-in-a-smart-contract-based-research-platform/
share
https://steemit.com/inovativebioresearch/@egetror/innovativebiosearchbringsinasmartcontractbasedresearchplatform-5vmkoaey60
https://twitter.com/CryptonetMe/status/992798721124397056
https://www.facebook.com/groups/871053179722394/permalink/952456988248679/

The ICO was cancelled, the token sale (presale and ICO) never actually took place, and the tokens were airdropped as a free reward to the participants of the bounty campaign https://bitcointalk.org/index.php?topic=3385669
 

EDIT.

Correcting this old incorrect information so as to prevent the spread of incorrect information. The ICO was cancelled, the token sale (presale and ICO) never actually took place, and the tokens were airdropped as a free reward to the participants of the bounty campaign https://bitcointalk.org/index.php?topic=3385669
 

i have read about project, so excited. Keep going.

Hello)
Where can I see video your product?

EDIT.

Correcting this old incorrect information so as to prevent the spread of incorrect information. The ICO was cancelled, the token sale (presale and ICO) never actually took place, and the tokens were airdropped as a free reward to the participants of the bounty campaign https://bitcointalk.org/index.php?topic=3385669
 

Great. Our INNBC Token is now officially verified by etherscan  :)

https://etherscan.io/token/0x85558055812f19eb084b8ba327470e84ad795b11

HOW WE OPERATE

For research projects, Jonathan Fior works as PI (principal investigator), conceiving the experiments and writing the experiment protocol. The work is then commissioned to a Contract Research Organization (CRO), which physically performs the experiments. Jonathan Fior then supervises all aspects related to the research communicating closely with the CRO. Once the experiments are completed, he analyzes the results and writes a scientific paper, which is published in a peer reviewed scientific journal. This means that although our team is not a large team, we actually have companies with 100+ people working for us. This way we can keep a small, yet strong and great, team. To maximise results  and reducing costs, we perform our highly specialized research by partnering with state-of-the-art CROs and Institutions. Some CROs we hired in the past are listed below

AXENIS (http://www.axenis.fr)

BERTIN PHARMA (http://www.bertin-bioreagent.com)

Social media links:

Jonathan Fior, Owner and Chief Scientific Officer. He is the head of the company.  
Facebook (https://www.facebook.com/jonathan.fior82)
Twitter (https://twitter.com/jonathanfior)
Pubmed (https://www.ncbi.nlm.nih.gov/pubmed/?term=jonathan+fior)

EDIT.

Correcting this old incorrect information so as to prevent the spread of incorrect information. The ICO was cancelled, the token sale (presale and ICO) never actually took place, and the tokens were airdropped as a free reward to the participants of the bounty campaign https://bitcointalk.org/index.php?topic=3385669
 

EDIT.

Correcting this old incorrect information so as to prevent the spread of incorrect information. The ICO was cancelled, the token sale (presale and ICO) never actually took place, and the tokens were airdropped as a free reward to the participants of the bounty campaign https://bitcointalk.org/index.php?topic=3385669
 

awesome project, following closely.

Thank you very much. We need your support to make this project a success not just for the blockchain industry but for the biotech industry as well.

Thanks for the support. Really appreciated.

Can I have more info on Token distribution?

The ICO was cancelled, the token sale (presale and ICO) never actually took place, and the tokens were airdropped as a free reward to the participants of the bounty campaign https://bitcointalk.org/index.php?topic=3385669
 

EDIT.

Correcting this old incorrect information so as to prevent the spread of incorrect information. The ICO was cancelled, the token sale (presale and ICO) never actually took place, and the tokens were airdropped as a free reward to the participants of the bounty campaign https://bitcointalk.org/index.php?topic=3385669
 

Thank you very much for the interest in the project. This is a long term project that involves not just the blockchain implementation but our AIDS cure research as well :)

This is a type of a very successful project.

INNOVATIVE BIORESEARCH is a project that focuses on new healing research on HIV, cancer and regeneration research. What is the specific target market of people affected by HIV or humanitarian institutions?
what kind of community will be built?

Thanks for your question. The target of our medical treatment is the HIV seropositive population.

Great explanation, thanks for clarifying

The INNBC project is the perfect solution for people with AIDS. With this project will greatly assist the medical world in finding a cure from this deadly disease

INNBC is a great idea to help people with this deadly disease, with a special research on AIDS and will ease the burden of AIDS sufferers

You are welcome. Please feel free to ask any other question.

Thanks. This is our mission.

Your project is exciting: biotech background is very solid and backing your currency with physical goods is appealing. I have some questions: 1) if I transfer your tokens to ETH wallet, what will be the transaction fees? 2) what else except JDM cars can I buy for the tokens? 3) when will exchange prices be available?

Hello, thanks for your positive feedback and your questions.

1)if I transfer your tokens to ETH wallet, what will be the transaction fees?

Correcting this old incorrect information so as to prevent the spread of incorrect information. The ICO was cancelled, the token sale (presale and ICO) never actually took place, and the tokens were airdropped as a free reward to the participants of the bounty campaign https://bitcointalk.org/index.php?topic=3385669
 

2) what else except JDM cars can I buy for the tokens?

Edit. Ico was cancelled. We still have a deal with a local JDM import business in the UK to get a discount if you hold INNBC. Further partnerships will be announced.

3)when will exchange prices be available?

Edit. Ico was cancelled. INNBC will be provided by users on decentralized exchanges after initial airdrop distribution and a price will be the result of the resulting market.

Thank you very much. We are getting a lof of interst from venture capitalists as well, who do not fall for marketing and only invest in solid projects.

Any question we are here to answer :)

Thank you very much for the useful response. Emission price is quite good. Are JDM cars of only one model available?

We are focusing on the models that have the greatest market value as collector items. That is, all Nissan Skyline GTR series, so R32, 33, and 34. The R34 GTR in particular almost doubled in price during recent years. In 2014 it was possible to find mint examples for around 39K Pounds, while now you have to spend at least 60-70k pounds for an example in the same conditions. That is why these cars are such a solid investment. It's becoming increasingly difficult to source them, so they are going up in value considerably each year. And as our stock of JDM cars will appreciate, I expect INNBC Tokens to appreciate as well, as they are directly backed by the value of these cars.

Other JDM cars that we will have available are Toyota Supras, Mitsubishi Evolutions, and Subaru Imprezas.

Can you ship overseas?

Of course. Worldwide shipping service available. The vehicles are sourced from Japan and shipped to the UK first, where they are inspected, serviced and registered. Then, we can ship them worldwide.

http://spiderman22.altervista.org/rsz_rsz_img_2692.jpg

Thank you for answering my question.

You are welcome  :)

Any other question feel free to ask :)

Big press release coming.

Thank you very much for the support :). The problem is that the legit projects are buried under the tremendous amount of scamcoins and so it is difficult to emerge.

I believe that INNOVATIVE BIORESE,though small, but fairly strong team.Thanks to this,I conclude that this platform has a chance to raise the necessary amount and successfully run the application.

Thank you very much. This is an uncomplete list, just to give an idea of media coverage and general interest in our project by international media outlets.

Being mentioned on PRnewswire and Yahoo Finance is a badge of trust for a company, which is crucial during a token sale to distinguish legit projects from scamcoins.

Blockchain specialized media reporting the news as well.

http://www.theblockchaindomain.info/news/2018/05/17/8756430.htm

Yes, we work by partnering with big companies to perform the specific task we need. It's a very efficient way to lower costs and maximize profits.

The team are hard working they answer all of supportor's question

We love what we do and we are here to answer any question.

Continue to develop this project to help heal people with AIDS. It seems that many will support this project, because this penyya bit becomes a serious problem in various countries.

The team are hard working
Hope a suceed future for you :)"

I support this project 101%

The problem of cancer for many centuries remains not defeated.And you know, I am pleased that the world with the advent of blockchain technology can somehow develop in this direction,the team of young developers has a lot of experience and a personal vision of how people can fight serious diseases.I hope that they will succeed.

As you mention cancer, I would like to share a little story regarding our paper on salamander regeneration as a model for developing novel cancer treatments (http://www.jcancer.org/v05p0715.htm (http://www.jcancer.org/v05p0715.htm))

When I wrote the paragraph entitled "Salamander Regeneration and Cancer", I was asked by the journal why I didn't mention more modern studies exploring the ability of salamanders to cure cancer in cells of other species, such as frogs, transplanted into salamanders. The reason is simple. There are no modern studies exploring such amazing natural ability to cure cancer in salamanders, which could lead us to develop a cure for cancer. Research in this area was basically interrupted around the 1948, with the study of Rose SM being the last of its kind (Rose SM, Wallingford HM. Transformation of renal tumors of frogs to normal tissues in regenerating limbs of salamanders. Science. 1948;107:457). We believe this is unacceptable, and our mission is to continue this kind of research, which was simply left to die by the academic world.

This is really an interesting project. It touches on important vital issues for today, I am glad that such promising projects are being created. I think this will be useful for many people. I think many will agree that this is an innovative project. I wish you good luck and development, I will follow the topic.

Wow, biotech ICOs looks trendy nowadays. Just participated in Shivom ICO, it was completely sold out in 8 minutes!  it seems to me that you guys have all the chances to raise funds.
Moreover your project is not about money, it has real value and can change our lives to the better!

Quite an interesting project, I have not seen such ideas for a long time. The project is necessary and relevant. New projects in the field of medicine aimed at a healthy lifestyle are already coming out weekly, and this personally pleases me. I believe that everything related to medicine and how it can help a person and his health should develop and improve. In so many competitive environments, the really necessary ones will develop.

announcement only 3 team members. do you have any advisors? Do you plan to expand the team? or can you already have news on this?

As you can see we perform biomedical reserch, and you can check our latest publication exploring SupT1 cell infusion as a possible HIV therapy

https://www.ncbi.nlm.nih.gov/pubmed/27128948 (https://www.ncbi.nlm.nih.gov/pubmed/27128948)

Therefore, our team is perfectly capable of doing the job, as is. This is the difference between our ICO and other ICOs. Our project is based on a real business and we have been doing this for years; it's not a collection of fancy presentations.

HOW WE OPERATE
For research projects, Jonathan Fior works as PI (principal investigator), conceiving the experiments and writing the experiment protocol. The work is then commissioned to a Contract Research Organization (CRO), which physically performs the experiments. Jonathan Fior then supervises all aspects related to the research communicating closely with the CRO. Once the experiments are completed, he analyzes the results and writes a scientific paper, which is published in a peer reviewed scientific journal. This means that although our team is not a large team, we actually have companies with 100+ people working for us. This way we can keep a small, yet strong and great, team.


Because we perform the core work internally, and then outsource the rest to big companies with 100+ people (e.g., Axenis (http://www.axenis.fr/), Bertin Pharma (http://www.bertin-bioreagent.com/)), we can operate with a small team.

EDIT.

Correcting this old information. The ICO was cancelled, the token sale (presale and ICO) never actually took place, and the tokens were airdropped as a free reward to the participants of the bounty campaign https://bitcointalk.org/index.php?topic=3385669
 

One key difference though is that they do not actually perform biomedical research. They are only developing the software solution, while we perform actual AIDS cure research. The implications are substantial as it means our Token utility is directly related to our research.  

Yeah, that's right. You have real utility token. And I have never met before any ICO devoted to AIDS cure research. And you bring value to the people.
If I have some tokens, what can you provide me in your platform?

Thank you very much for the positive feedback :)

this project is really good and will be useful to many people in the world. but it needs a lot of funds for development. I hope many investors will be interested to participate in this project.

This is another project aimed at humanitarian goals for public health. The project conducts research following a test method and allows any contractual partner to have a clinical investigation to enter data generated by their test. In this way, the project can own many people's intellectual property. I believe that successful projects will be of great significance to public health.

Thanks. We are a biotech company performing novel biomedical research, and scientific research is something serious. Behind our project there are therefore many years of hard work and investments to perform and publish our research.

EDIT. The ICO was cancelled, the token sale (presale and ICO) never actually took place, and the tokens were airdropped as a free reward to the participants of the bounty campaign https://bitcointalk.org/index.php?topic=3385669
 

There are several good reasons to have clinical data on the blockchain.

•Immutability. Scientific data need to be immutable. Once a study is peer reviewed and published, its data must be permanently stored and never altered. In the blockchain, all data is stored in every single node, never ceasing to exist, and always staying on the blockchain. It is immutability that gives the blockchain its openness and BFT (Byzantine Fault Tolerance).

​•Decentralization. The blockchain is designed to be distributed and synchronized across networks, making data freely available to anyone. We believe that scientific data should be shared and not being hidden behind a firewall.

​•Security. The kind of transactions that can be performed are strictly defined in advance and stored in the blockchain as “smart contracts”; this prevents fraudulent data from being added to the blockchain thus ensuring integrity of the database. By contrast, it would be much easier to compromise a centralized database.

​In conclusion, although it is true that such an application could be implemented with a centralized system, decentralization is the only way to ensure the data is not manipulated, and all information is pubblicly available in a platform that can't be influenced by the will of any particular entity or government. Decentralization is essential to hand over administrative authority from central institutions managing the data, such as governments and private entities, to the collectivity. In fact, if the database is controlled by one single entity, being it a private entity or government, it means that such entity has total control over the database, and such control can be influenced by personal conflicts of interests. Therefore, decentralization is the only way to ensure that scientific data become public property. In addition, in terms of costs, creating an infrastructure ensuring the same level of data integrity protection of a smart contract deployed on the Etherum blockchain, which is basically impossible to compromise, and most importantly, maintaining such a platform up and running, would simply not be feasible.

Possible listing of our Token on Evercoin (https://evercoin.com/).

EDIT.

Correcting this old incorrect information so as to prevent the spread of incorrect information. The ICO was cancelled, the token sale (presale and ICO) never actually took place, and the tokens were airdropped as a free reward to the participants of the bounty campaign https://bitcointalk.org/index.php?topic=3385669
 

Wow, these are nice ICO reviews. Now I see that your company is credible one and what I like more is that you bring real value to people.
If you will be able to solve AID issue and find a solution, you will make a breakthrough

Thanks. Correcting this old incorrect information so as to prevent the spread of incorrect information. The ICO was cancelled, the token sale (presale and ICO) never actually took place, and the tokens were airdropped as a free reward to the participants of the bounty campaign https://bitcointalk.org/index.php?topic=3385669
 

I've recently noticed your ICO. The point is that nobody before never invented something against AID and cancer or their inventions are useless.
What distinct you from numerous projects without any results. Why do you think that you will invent medicine against AID?

I tried to register but I do not receive any confirmation mail. Tried with gmail address and with a self hosted email service. Already checked the log files, but there is no email incoming.

Hello,

EDIT.

Correcting this old incorrect information so as to prevent the spread of incorrect information. The ICO was cancelled, the token sale (presale and ICO) never actually took place, and the tokens were airdropped as a free reward to the participants of the bounty campaign https://bitcointalk.org/index.php?topic=3385669
 

Actually, we have conceived a very innovative cell-based therapy for HIV that uses the SupT1 cell line as a decoy target for the HIV virus. Our approach is unique as no other therapy tried to use a permissive T cell-line as a decoy target for the HIV virus. Furthermore, this is a cell-based approach, which is something completely different than traditional drug based approaches that failed to produce an AIDS cure. So we are not in need of inventing a new solution, we just need to further develop the HIV therapy we have already conceived, completing preclinical animal research and move to human trials. I'll post some information from our website (https://www.innovativebioresearch.com/hiv-cure-research) regarding our novel AIDS therapy solution.


An Overview of SupT1 Cell Infusion Therapy, our Novel Cell-Based Therapy Solution for HIV
​

HIV infection usually leads to a progressive decline in number and functionality of CD4+ T lymphocytes, resulting in AIDS development. As explained in Jonathan Fior’s papers [1–3], the HIV virus has a higher tropism for SupT1 cells than for primary CD4+ T cells. Several hypotheses have been proposed as an explanation, most notably the higher surface expression of CD4 and CXCR4 receptors in SupT1 cells. In addition, in vitro studies of HIV evolution show that persistent growth in the SupT1 cell line results in a less cytopathic virus with a reduced capacity for syncytium formation, a higher sensitivity to neutralization, improved replication in SupT1 cells and impaired infection of primary CD4+ T cells [4–6]. Accordingly, Jonathan Fior proposed the infusion of irradiated SupT1 cells as a cell-based HIV therapy to exploit the therapeutic potential of these phenomena [1–3]. The rationale behind this approach is that moving infection toward the inoculated cells should prevent infection and depletion of the patient’s own CD4+ T cells and, therefore, AIDS. In such a strategy, SupT1 cells would act as a “decoy target” for the HIV virus to prevent CD4+ T cell depletion as well as to render the virus less cytopathic. As previously mentioned, in vitro studies of HIV evolution show that prolonged replication in SupT1 cells renders the virus less cytopathic and more sensitive to neutralization. Accordingly, replication of the virus in the inoculated SupT1 cells should also have a vaccination effect; that is, the therapy should also induce the virus to become progressively less aggressive and harmful for the patient. The use of SupT1 cells as a decoy target for HIV has been investigated in vitro and in vivo, with interesting results [1,3]. In vitro data showed that, when primary CD4+ T cells are infected with HIV in the presence of SupT1 cells, the preferential infection of SupT1 cells can spare primary CD4+ T cells from infection and depletion. In vivo data in humanized mice showed that significantly lower viral replication (~10-fold) and potentially preserved CD4+ T cell frequency at Week 1 was scored in animals treated with SupT1 cell infusion. Of note, one animal exhibited a sustained decrease in HIV replication and CD4+ T cell depletion (no virus detected anymore at Weeks 3 and 4), a result that may hold the key to future HIV treatments. Given the urgent and global need for a cost effective cure for HIV, we believe that the millions of people infected by this terrible disease deserve highly innovative HIV cure research strategies, such as SupT1 cell infusion therapy.

In summary, these are some of the potential therapeutic benefits of this cell-based treatment that go beyond what can be achievable with traditional antiretroviral therapy (cART):

1)The vaccination effect. As previously mentioned, SupT1 cells have been shown to have a very powerful vaccination effect in vitro [4–6]. In this regard, in vitro studies of HIV evolution showed that upon prolonged replication in SupT1 cells, the X4 HIV-1 LAI virus evolves toward a less virulent phenotype with a reduced capacity for syncytium formation, thus losing the main cytopathic feature characterizing X4 strains, and most notably the virus adaptation to replicate in SupT1 cells results in gradually losing the ability to replicate in primary CD4+ T cells [4]. In addition, the variation to neutralization sensitivity after viral growth in tumor T cell lines has also been examined. Interestingly, one study reported that primary isolates that were initially resistant to neutralization acquired sensitivity to neutralization after continuous growth in tumor T cell lines, and that the sensitivity to neutralization progressively increased during the days of culturing [5]. Specifically, it was shown that after 14 days in continuous culture, 100 micrograms/mL of rsCD4 (recombinant soluble CD4) were needed to neutralize 1 TCID of primary isolate, while only 0.3 micrograms/mL of rsCD4 were needed to neutralize 1 TCID of the virus after 75 days in continuous culture. This means that there was a 300 fold increase in virus sensitivity to neutralization after prolonged replication in a tumor T cell line, which is really something remarkable. All these phenomena could therefore harbor a significant therapeutic potential that could be exploited with SupT1 cell infusion therapy to induce HIV infection to evolve into a more tractable state for therapy.

2)Potentially no organ toxicity; cART is a drug based treatment and as such is associated with organ toxicity because the drugs are metabolized by various organs. By contrast, SupT1 cell infusion is a cell-based treatment and there is no chemical substance injected into the body that needs to be metabolized, which could significantly improve the quality of the patient's life.

3)Be effective in patients in a terminal state of disease that developed drug resistant and very aggressive HIV strains. When a patient is treated with cART, the virus fights back because it strives to survive, which can result in the development of very aggressive and drug resistant HIV strains, especially in the terminal stage of the disease and in such cases cART becomes ineffective. By contrast, SupT1 cell infusion therapy provides the virus with a permissive cell-line in which it can preferentially replicate, so that a peaceful coexistence between virus and host becomes possible, which could dramatically improve the patient's health as the virus infection progressively moves toward the inoculated SupT1 cells and the virus becomes increasingly less pathogenic for its host.

4)Possible association of the treatment with novel molecular compounds such as a Vif-inhibitor to act on HIV reservoirs. The HIV-1 Vif protein is essential for viral replication in primary CD4+ T cells but not in SupT1 cells [1]. Accordingly, pharmacologic inhibition of Vif could be combined with SupT1 cell infusion to further restrict viral replication to the inoculated SupT1 cells. Considering that APOBEC3G is expressed by different cell types, such as neuronal cells, astrocytes, and macrophages [2], pharmacologic inhibition of Vif may also have the benefit of acting on HIV reservoirs in the brain and other body areas. There are several molecules with promising anti-Vif activity currently being tested [2]. Similarly, other HIV-1 accessory proteins that are not essential for replication in SupT1 cells (e.g., Vpr, Vpu, and Nef [3]) may also be the target of pharmacologic inhibition. It is important to point out that these drugs would not affect virus replication in the inoculated SupT1 cells, and therefore in combination with SupT1 cell infusion therapy, there should not be development of drug resistance normally associated with drug based treatments.

​5)A cost effective AIDS cure solution. Our mission is to provide a cost effective cure solution for AIDS. In contrast with traditional cell-based and gene-based therapies that make use of modified autologous cells and are therefore very expensive and often unpractical for a large scale application, using a standardized T cell line such as the SupT1 cell line should significantly reduce the treatment costs associated with SupT1 cell infusion therapy, allowing access to the therapy where access to traditional HIV therapies is restricted by economic and social limitations. The social and economical impacts of a low cost HIV cure solution would be enormous.

Below some considerations with regard to potential issues:

1)Safety. We take this issue very seriously and are committed to performing very rigorous preclinical research to ensure there is enough data on safety to obtain approval from regulatory agencies for human experimentation. In this regard, injection of irradiated tumor cells as a therapy is already performed in cancer vaccination. In such cases, irradiating the cells prior to inoculation has been shown to ensure treatment safety both in animal and clinical studies [7]. We used the same protocol used in cancer vaccination studies (i.e., 30 Gy of radiation dose for the cells), which resulted in safe in vivo inoculation in our animal study as well [3]. Specifically, all animals successfully survived the treatment and presence of SupT1 cells was almost undetectable at late time points, which means that irradiating the cells prior to inoculation efficiently prevented SupT1 cell replication. Furthermore, we infused high doses of cells (40 million SupT1 cells were infused weekly), which in a highly immunodeficient mouse strain would rapidly lead to animal death in case of tumor development. Therefore, based on the clinical data we already have from cancer vaccination studies, and from the results of our first animal study, we believe that meeting the safety standards required for human trials is something feasible.

2)Rejection issues. Tumors can develop because tumor cells are able to evade immune recognition. For example, SupT1 cells do not express HLA-DR, which is an antigen highly associated with immune recognition [8]. Accordingly, given the tumoral nature of SupT1 cells, they should be significantly less immunogenic than normal cells and as such should survive in the patient long enough to provide a therapeutic effect. However, it is possible that the HIV virus will eradicate the cells faster and more efficiently than the immune system itself in any case.

References

1. Fior J. An initial in vitro investigation into the potential therapeutic use of SupT1 cells to prevent AIDS in HIV-seropositive individuals. PLoS ONE. 2012;7:13.

2. Fior J. Is a pacific coexistence between virus and host the unexploited path that may lead to an HIV functional cure? Viruses. 2013;5:753–757.

3. Fior, J. SupT1 Cell Infusion as a Possible Cell-Based Therapy for HIV: Results from a Pilot Study in Hu-PBMC BRGS Mice. Vaccines. 2016, 4:13.

4. Das, A.T.; Land, A.; Braakman, I.; Klaver, B.; Berkhout, B. HIV-1 evolves into a nonsyncytiuminducing virus upon prolonged culture in vitro. Virology. 1999, 263:55–69.

5. Turner, S.; Tizard, R.; DeMarinis, J.; Pepinsky, R.B.; Zullo, J.; Schooley, R.; Fisher, R. Resistance of primary isolates of human immunodeficiency virus type 1 to neutralization by soluble CD4 is not due to lower affinity with the viral envelope glycoprotein gp120. Proc. Natl. Acad. Sci. USA. 1992, 89:1335–1339.

6. Moore, J.P.; Burkly, L.C.; Connor, R.I.; Cao, Y.; Tizard, R.; Ho, D.D.; Fisher, R.A. Adaptation of two primary human immunodeficiency virus type 1 isolates to growth in transformed T cell lines correlates with alterations in the responses of their envelope glycoproteins to soluble CD4. AIDS Res. Hum. Retroviruses. 1993, 9:529–539.

7. Salgia R, et al. Vaccination with irradiated autologous tumor cells engineered to secrete granulocyte-macrophage colony-stimulating factor augments antitumor immunity in some patients with metastatic non-small-cell lung carcinoma. J. Clin. Oncol. 2003, 21:624–630.

8. Dufresne I, et al. Targeting lymph nodes with liposomes bearing anti-HLA-DR Fab′ fragments. Biochim Biophys Acta. 1999, 1421:284-94.

Now, in the previous post I gave you a technical explanation about why our treatment is novel and is exploring approaches never tested before. However, there is also an economic explanation why there is such an extreme lack of innovation in this field.

There is the huge business of the pharmaceutical corporations selling expensive HIV drug, which aim to make as much profit as possible off of AIDS. These companies would never support the development of a low cost AIDS cure because it would put an end to their huge profits. This is precisely why we need a project such as this one in our society.

There were 36.7million people infected by HIV globally in 2016, 17.5million of which were left untreated, according to UNAIDS. Our mission is to develop a low cost cell-based therapy solution for HIV to allow access to the treatment for those individuals who are normally left untreated due to social and/or economic limitations.

If your research will be successful, that is fantastic... good Luck

AIDS is currently one of the most threatening humans to the horror virus. There is no good therapy so far. Many medical experts have tried to solve the virus. Many countries’ governments have given a lot of financial support for research to overcome AIDS virus. If your project can solve this problem, ICO is not needed at all.

There is very poor funding with regard to exploring innovative solutions, take it from people who does this as a job ;).  So many promising projects are left unfunded by government agencies. This is why ICOs can be, without any doubt, a necessary and novel tool for funding potentially vital research that would have otherwise been left to die by the academic world.

Because governments can easily dictate what researches should be funded and developed, and because this process can also be influenced by possible conflicts of interests (e.g., pharmaceutical corporations selling HIV drugs not willing to lose their marketshare if an AIDS cure is developed), ICOs can be a necessary tool for our society to decentralize the funding power from government agencies/pharmaceutical corporations to the collectivity.

The INNBC Token will be accepted as a means of payment for all our furture medical services and products.

EDIT.

Correcting this old incorrect information so as to prevent the spread of incorrect information. The ICO was cancelled, the token sale (presale and ICO) never actually took place, and the tokens were airdropped as a free reward to the participants of the bounty campaign https://bitcointalk.org/index.php?topic=3385669
 

Any other question we are here to asnwer.

So as our Token is spendable to buy jdm cars, we always monitor the market for these cars. So I just got back from a conversation with one of our contacts importing cars from Japan. The Subaru Impreza WRX Type RA LE just went up in value considerably in the recent months. Just a couple of months ago it was possible to buy one for 13k pounds, now they go for 20k pounds. This really shows that these cars are a very solid investment. Because our Token is backed by the value of these cars, this is going to preserve the INNBC Token value.

Unlike other coins that are backed just by hopes and dreams, and their price can go up and down to whatever value the market feels, our Token is backed by the value of real assets, and its price on exchanges should reflect that.

Any issue or question about the Token sale let me know.

How nice to be aware of the fact that in a short time humanity will learn to fight all diseases and prevent them in advance. This is one of the few projects that we really need, which move us forward.

it would be great if this project was to develop.
his idea is very noble and it would have helped a lot to humanity.
health is the main thing in life and it improves the project itself.

Continue to develop this project to help heal people with AIDS. It seems that many will support this project, because this penyya bit becomes a serious problem in various countries.

WE CAN NOW ACCOUNCE THAT WE MADE AN AMAZING PARTNERSHIP WITH THE FIXY NETWORK (http://fixyapp.io/)

Article published on CCN.

https://www.ccn.com/sell-your-tokens-loaded-on-gift-cards-and-50-000-for-selected-startup-projects/

Sell Your Tokens Loaded on Gift Cards and $50.000 for Selected Startup Projects


Advertising over Fixy Network App
One of the most important things investors should look out for when investing in an ICO is whether or not a token will be able to gain user adoption and be useful for solving problems with its application in the real world. Unfortunately, many projects are simply bad ideas from the start.

In the context of fundraising through ICO, we may see an increasing amount of fresh capital influx to crypto market capitalization as cryptocurrency gaining more exposure In the mainstream media and considering that regulation initiative by G20 countries will soon come to provide legal certainty for cryptocurrencies and protections from the prevalent ICO-related frauds.

Up until now, many investors perceive the facts that investing in ICOs is a hard thing to do. Although many are interested in contributing to ICOs, they are unable to do so because they perceive the process of getting their first crypto and its wallet as a mode of payment for ICOs are way too complicated for them.

Gift cards provided by Fixy Network will give an opportunity to people to get into the cryptocurrency-world without going through lengthy verification process since it provides a convenient shortcut. ICO’s Gift cards will be sold like online credit cards on a website, providing an easy access for everyone around the globe. After purchase, they can be claimed by mail or post.

By using Gift cards provided by Fixy Network, potential investors can invest to any ICO that uses erc20 tokens with their FIAT money and directly receive a gift card that loaded with the ICO’s token. This method gives an extremely competitive advantage for any ICO to obtain new investors since it eliminates the pain point to invest in any ICOs such as the need for buying cryptocurrency through exchanges with its fees and setting up crypto wallets which seem still perceived as complicated steps by many new investors.

New Partnerships Announcement
In this opportunity, FIxy Network is also pleased to announce 3 new partnerships after successfully secured multiple partnerships in the past :

Agentmile (agentmile.com). The world’s first decentralized CRE leasing platform powered by Al. Agentmile enables brokers and landlords to list their commercial properties on our blockchain powered MLS and offer enhanced leasing capabilities, management and reporting.

Innovative Bioresearch (innovativebioresearch.com). Innovative Bioresearch Ltd is a privately held biotech company, with the goal of bringing innovation to the field of HIV, cancer and regeneration research. In addition, the INNBC Token will be spendable to buy classic iconic JDM cars from our JDM online garage and is therefore backed by the value of actual physical goods.

More partnerships announcement is already in the pipeline and will be announced soon, stay tuned!

Fixy Exchange Listing Opportunity
Last but not least, Fixy network is looking to build an altcoin exchange and all partnership ICOs will be listed on the exchange. Altcoins exchange feature on Fixy smartphone app will provide users with ease of access and convenience, ensuring a steady growth of user numbers. Should a startup wants to list its coin on the exchange, the fee will be paid in FXY Token.

Fixy Token will be listed 8 June 2018 on popular exchanges and 25 June is token burn of 85% total supply scheduled. FXY Token price is with 2$ fixed for B2B deals. Actually it can be traded dit for 0.1$ on forkdelta.

I wish that you guys will have a successful ICO and implement this project because it will be a big impact to everyone in the world and if these kind of platform will success in the future then one thing is for sure that people around the globe will adopt the Blockchain technology and Cryptocurrency because it can solve the problem of humanity.

EDIT.

The ICO was cancelled, the token sale (presale and ICO) never actually took place, and the tokens were airdropped as a free reward to the participants of the bounty campaign https://bitcointalk.org/index.php?topic=3385669
 

This is really an interesting project. It touches on important vital issues for today, I am glad that such promising projects are being created. I think this will be useful for many people. I think many will agree that this is an innovative project. I wish you good luck and development, I will follow the topic.

This is affirmative, especially good news for scientific research and human health development, which will bring more people into it.

this will really motivate research work into the area of AIDS hopefully cure maybe found.who knows.

Thanks. We are working hard to bring innovation to the field.

I like that the developers have the idea This is an ICO to support research in the field of AIDS treatment, and also to develop an application that provides, on the one hand, a decentralized database for clinical data derived from future human trials, to overcome the limitations of current centralized database, and on the other - a social platform for the seropositive HIV community and future services. ;)

In favor of the potential success of the project and says the experience of its leader, who is already the author of promising research and scientific works in the field of search of means of treatment of HIV infection and cancer.

Got any question? Just ask.

Funding AIDS research and data analysis is a very difficult point, but I am sure it is an opportunity to benefit people all over the world.

It's nice to know that the goals of this project have a big help in society. And we know that the cases of having AIDS now are increasing everyday. I hope the team behind this will succeed on their mission here in crypto world.

Traditional funding is way insufficient so we need new ways to support AIDS research. An Ico can be a very novel way for such a task. And it could also generate a great return for investors. But we need your support. If you invest is useless scam coins that serve no real purpose and not in solid projects you will kill the market.

Thanks for the support!

Thanks for the support.

Crypto can be something very useful to overcome the limitations and centralized control of the actual funding system from government agencies.

The idea of the project is noble, but I have several questions. What is the economy of this project? How will the price of the token be supported?

To be honest, this is what I ask myself each time I see all those coins backed by nothing other than hopes and dreams, while our Token is backed by real assets such as our biomedical research, which is very valuable. With a potential target of 36.7million HIV infected individuals globally, our AIDS cure solution could generate 9billion/year in revenue by successfully targeting 20% of the global HIV infected population, which if our therapy will prove to be safe and effective as an HIV cure we believe is a realistic goal. We will accept the INNBC Token as a means of payment for all our medical products and treatments, which means the price of the Token will backed by the value of our pharmaceutical products.


EDIT.

The ICO was cancelled, the token sale (presale and ICO) never actually took place, and the tokens were airdropped as a free reward to the participants of the bounty campaign https://bitcointalk.org/index.php?topic=3385669
 

GREAT NEWS!!!


INNBC Token accepted for listing on the IDEX exchange, and should be listed tomorrow.

Edit. Not tomorrow, today  8)

Happy trading with INNBC  ;D

Hi everyone! Just added this incredible ICO to my website   https://findico.io/ico/innovative-bioresearch   Findico.io is an online informational platform that claims to offer ICO ratings from top investors and experts. Using the information on the website, you can “invest smarter” and pick the best ICOs. In addition to rating ICOs, Findico offers ICO consulting services and we can help companies with all stages of their ICO.

INNBC listed on DAKUCE exchange

https://dakuce.com/trade?symbol=INNBC_BTC
https://dakuce.com/trade?symbol=INNBC_ETH

BASE.INFO (https://base.info) team has interviewed Jonathan Fior (https://base.info/person/jonathan-fior) the CEO of Innovative Bioresearch (https://base.info/ico/innovative-bioresearch) project. We have asked the most topical questions to get acquainted with the project and to learn the future plans of the Innovative Bioresearch team.

https://base.info/news/exclusive-interview-innovative-bioresearch-privately-held-biotech-company (https://base.info/news/exclusive-interview-innovative-bioresearch-privately-held-biotech-company)

https://storage.base.info/source/generated/news_banner_712_1.png?v=1536592119 (https://base.info/news/exclusive-interview-innovative-bioresearch-privately-held-biotech-company)

https://t.me/joinchat/AAAAAFDcUwrnS0vyWPa-_w

https://t.me/joinchat/AAAAAFDcUwrnS0vyWPa-_w
INNBC will vote  list soon in  top KOREA exchang pump up100X very soon🏬🚀🚀🚀🚀🚀🚀🚀🚀🚀🚀 : https://coinone.co.kr/exchange/trade/innbc/krwhttps://www.coinbit.co.kr/trade/order/innbc-krw   https://www.gdac.co.kr/exchange/INNBC/KRWhttps://www.cpdax.com/trade/INNBC-KRW   https://www.bithumb.com/trade/order/INNBC https://www.korbit.co.kr/markets/?market=innbc-krw

We are glad to announce that INNBC is now listed on Mercatox exchange with INNBC/BTC and INNBC/ETH markets available for trading:

https://mercatox.com/exchange/INNBC/BTC
https://mercatox.com/exchange/INNBC/ETH

https://twitter.com/mercatoxcom/status/1070275720625221633?s=21

Good luck in the forthcoming trades and let’s go to the moon🚀🚀🚀
#BTC #ETH #INNBC #SELL #BUY #EXCHANGE

On January 2019 we upgraded the Token contract in anticipation of the release of our revolutionary "You're not alone" app, while at the same time we felt the need, listening to our community feedback, to support different markets. So we performed a Token Swap/Fork and created twoo new upgraded Tokens; INNBC (InnovativeBioresearchCoin, https://etherscan.io/token/0xEb70bbf15Fd1c0542896A80f2aF90C8FD40a9ec5) and INNBCL (InnovativeBioresearchClassic, https://etherscan.io/token/0x8CC3E2BdC17682c622eB789EDA23FbD6988C84Da). INNBC is a Token intended to support those markets with a more restricted trading price range, while INNBCL will be listed in those more aggressive and speculative markets allowing a wider trading price range. INNBC and INNBCL will be both supported in our upcoming "You're not alone" app, although INNBCL token holders may be elegible for higher rewards due to the different nature of the supported markets.

​

We are developing the "You're not alone" application specifically for our research, to overcome the limitations of current centralized databases. However, we believe there may be interest in using our application by other research organizations. After all, this would be an application designed by a research scientist for research scientists. Our database will be open to any company or institution interested in using our app for storing their clinical data. Moreover, we will encourage them to do so as we believe that scientific data should be shared publicly. 4

Edit. "You're not alone" name changed to "INNBC DApp"

INNBCL NOW LISTED ON COINMARKET CAP!!!

https://coinmarketcap.com/currencies/innovative-bioresearch-classic/

INNBCL Coin Very Nice Future x1000

Congratulations INNBCL 🚀

INNBCL Same as Doge and BCN

Project is very interesting. Science can benefits a lot of we support correct research.

Great project....more power and success.....

Just to confirm as I just noticed o was holding a few of the first INNBC(old) tokens for a long time now and didn't realise. Are they basically now worthless or can I swap them for the new token?

Yes you can you need to show us your wallet for us to check.

Please note we opened a new official thread here https://bitcointalk.org/index.php?topic=5242368.msg54269473#msg54269473

Дoбpый дeнь!
Пoмoгитe пoмeнять мoнeты, пoжaлyйcтa. Boт мoй кoшeлeк 0x336Bbc17477F9E97C111deDB5398Dce9bdFbcFD5

Does anyone have an explanation for the constant increase in the total supply at innbc
That doesn't seem serious to me.
How many coins there are ultimately actually or come endlessly always new ones.

Now it's >254 billion and they're still adding regularly. Price is down 99,9999% since this thread was started.

They have not done any of the promised things, there are no results, you cannot do anything with the INNBC - except buy it.

And the promised "AIDS cure" is a fake. I wrote some things up on medium:
https://earlightswindle.medium.com/innbc-ruthless-health-research-scam-or-just-another-obscure-token-7b3bb176c4c6 (https://earlightswindle.medium.com/innbc-ruthless-health-research-scam-or-just-another-obscure-token-7b3bb176c4c6)

Last low was that the CEO lied about the whereabouts of the company, and misdirected investors to non-existing labs. Absolutely insane what's going on in that "community".

Your fraudolent fud article on medium has been removed after we pursue legal action as it was obviously against their policy. In fact, official science is dissussed by scientific publications on pubmed (https://pubmed.ncbi.nlm.nih.gov/), on which you have no publicaton record. Any qualified professional would immdiately identify themselves with their name and publications, so we strongly suggest to refrain from considering any medical information posted by anonymous users. INNBC delivered on their goal of developing a decentralized application to record on chain biomedical data. Dapp is live and we have an upcoming scientific publication discussing the results. INNBC DefiScience model involves some supply to be used for bulding products such as the HIV therapy and the DApps for science, along with staking and farming defi events. The model is clearly defined in the whitepaper. Worst of all, you are deceiving people using the warning posted on this thread against us, when we have nothing to do with the opening poster who originally created this thread, he is just a legendary member of this forum we paid fort creating this thread for us and he is not part of our team nor does he have any affiliation witn us. The warning is therefore not about us but about him "users have reported that they strongly believe that the creator of this topic is a scammer". We have nothing to do with the creator of this topic. For this reason, we then created an official thread directly managed by us.