Lost profit for SR.
Not necessarily. The prices might go down a little as more product comes in, but I suspect they'll make it up in volume. Just because it's legal for anyone to buy it now in a few states doesn't mean that they won't like the convenience of picking it up in the mail.
And besides, now those two states will become the biggest suppliers for the domestic market. If I were an SR merchant, selling weed, I'd move to Denver.