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Author Topic: Spartacus Letter  (Read 2249 times)
ICENI_Spartacus
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October 03, 2021, 12:31:46 AM
Merited by vapourminer (2)
 #121

We see this kind of thing not infrequently in medicine, and even more so in critical care. Drugs or treatments which show promising results in vitro, show promising results in rodent models, maybe even show promising results in healthy volunteers, but when we apply them to critically ill patients, they either don't work or even make things worse.

Take colloids for example. They were going to be the next big thing and replace crystalloids for treating septic shock. They provided a bigger increase in blood pressure than crystalloids, and this increase lasted longer. They stayed in the intravascular space longer, they caused less peripheral and pulmonary edema and fewer third space losses. They allowed us to wean vasopressors more quickly. They made all our numbers and parameters better. And then the studies came out which showed that actually they were pro-inflammatory, they were bad for the kidneys, and they worsened mortality. So we are back with crystalloids except in very specific cases.

Take ventilation for example. When we first ventilated patients, we used large tidal volumes and high respiratory rates to help clear CO2. We did this to get their PaCO2 down to a physiological level, which helped to correct the acidosis associated with sepsis and bring their pH back to a normal level, which definitely improved things in the short term, stabilized the patient, reduced the requirement for inotropes and vasopressors, etc. And then the studies likes ARDSnet came out which showed we were causing volutrauma and barotrauma and allowing what we call "permissive hypercapnia" with lower tidal volumes improved mortality.

So then we get a treatment like antioxidants, which logically should work, and which give good looking data in rodents or healthy volunteers, but when applied to a critically ill population, simply don't work.

Well, you're absolutely right. Something that seems promising in vitro is not always useful in vivo. A drug that works great on a cell culture may never even reach the cells in question when applied to a living body, which is basically a giant maze.

However, that's not what I meant. Look at those links I posted again. Many trials have failed to post any results at all, even over a year after their completion. Not positive, not negative. Nothing. No data. That's so frustrating to see.

Emphasis mine. These people would have had a near 100% mortality rate without intubation. I've intubated a lot of people with COVID, and in every single one they were critically hypoxic and, at most, a couple of hours from dying without intervention. It's also worth noting that the article with a mortality rate of 88% was published in April 2020, during the first wave, when we had no specific treatments for this disease. Less than a year later and the mortality rate is now down at 45% precisely because we have evidence showing us which "adjunct therapy", as you put it, is effective. As time goes on, and with other treatments being studied and widespread vaccination, that number will reduce further.

Isn't there anything that can be done in terms of surveillance and early treatment before they become critically hypoxic?

The public don't care. What can they do with knowledge that COVID causes severe DIC or pericarditis? They want to know when they can go on vacation again or go to a concert.

That's the wrong way of thinking about things. If there's no outreach at all, then people will become hostile and angry, simply because their bread and circuses are gone and they have no valid explanation for why this is the case, other than "there's a spooky pneumonia around".

I have seen so many instances where people go over the topic of COVID-19 death certificates, hear that a PE, stroke, or myocardial infarction killed someone who was sick with COVID-19, and then angrily grumble something about how hospitals are inflating COVID-19 numbers by designating deaths from infarcts as COVID deaths. I've spoken with a nurse who I see on my commute periodically, and he told me about a COVID-19 patient he saw who needed both her legs to be amputated from the knees down because of clots. People don't even comprehend the notion of an airborne virus that causes aggressive coagulopathy that can progress to disseminated intravascular coagulation. It does not compute.

I know they're trying to prevent a panic, but at this stage, more information is better. It has to be. What's going to fill the void if no one comes forward with answers? Long rants filled with angry and paranoid speculation? Mass unrest?

My condolences, sincerely. It's personal for a lot of us.

It is good to hear that the protocols for the ventilators have been adjusted and that mortality is dropping. Perhaps I came off as a little hyperbolic about them. I will have to correct that.

See? It's hard even for me, someone digging relentlessly into all this, to get up-to-date information on how patients are responding to adjustments in the protocols. Imagine the kind of dread and desperation for good-quality answers that the public must feel. Imagine how someone whose loved one is dying in the hospital feels. They don't know anything at all.

Back in February of 2020, I realized there was a shortage of PPE and equipment for healthcare workers that was about to make the following weeks and months into a living hell. I tried emailing HHS and the CDC about my concerns over supply shortages, but they never got back to me. Then, there were indeed shortages.

What we have is a crisis of trust. Public officials have done everything in their power to make millions of people very distrustful of them. The constant vacillation is appalling. First, masks are derided as useless, and travel bans are called racist. Then, they're mandatory; put these diapers on your face and cancel your travel plans. First, COVID is mostly transmitted by touch surfaces, then they say droplets, then they say aerosols. Two weeks to slow the spread and then it'll all be over, but it's actually two years and it's still going. The whole point of the stimulus checks was essentially to keep Wall Street afloat in the midst of an ongoing economic downturn due to the pandemic log-jamming just-in-time logistics, but we're told that this is to help people back up on their feet. Meanwhile, trillions of dollars were transferred from working-class people to the very rich.

Everything that they have done seems almost calculated to induce existential dread. People are demanding answers, but are receiving pepper spray and a truncheon to the face instead. Democracies have transformed, almost overnight, into brutal authoritarian hells. Everyone in the Anglosphere is watching Australia with open-mouthed horror and wondering if we're next.

How many people have lost their jobs over this? How many have slit their wrists in the bathtub or ODed on the sofa because they couldn't take it anymore?

Maybe if people hadn't been lied to and had their trust abused so flagrantly, we wouldn't be in this mess. People don't like to be turned into outcasts and pariahs in our own damn countries.

Mostly low quality evidence. Cohort studies or self selecting studies, low number of patients, confounding factors, etc. One of those studies you linked even found that physical activity was a risk factor for COVID. If you take high quality meta-analyses which only include high quality RTCs, such as the one I linked previously or this one - https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD015017.pub2 - we generally find very sporadic and inconclusive evidence. I'm not saying there definitely isn't something there, but there is no good quality evidence to support it at present.

Very disappointing. I would have hoped that there would be something even better than dexamethasone for treating COVID-19 hyperinflammation by now. Sad

A lot of people don't realize that antivirals can range from mildly toxic, like Ivermectin, to highly toxic and injurious to the liver and/or kidneys, like Kaletra and Remdesivir. Antivirals generally work by inhibiting the cellular machinery that viruses hijack to make their proteins. However, our own bodies need that machinery to express our own genes, too.

These patients' own bodies are killing them. It's not even really the virus itself; it's a SARS-like over-exuberant immune response, like carpet bombing an entire city with B-52s to kill a few guerrillas. Everything is a balancing act when one proposes to suppress the immune system. Too much suppression, and the patient ends up with co-infections, as was seen in India when the heavy use of steroids led to mucormycosis. Disabling the armaments of phagocytes, suppressing DAMPs, and preventing the activity of inflammatory transcription factors like NF-kB, AP-1 and STAT is not always beneficial.

Some inflammation is good, just not the crazy inflammation seen in COVID-19.

Almost all anti-vaxxers deliberately just turn a blind eye to published data and trials. I'm curious as to how you can understand how trials like these are the only way to reach firm conclusions and build an evidence base, but then simultaneously choose to ignore the evidence that the vaccine is reducing symptoms, reducing critical care admissions, and saving lives.

I am aware of the reports of lessened morbidity and mortality. What I'm worried about is ADE and the possibility that mortality from vaccine-related complications might eclipse any benefit over time, thus rendering the short-term benefits worthless. Yes, you're right in that quality, well-designed trials that produce good data are important, absolutely. However, all we have so far is a limited slice of time. We can make predictions, but we don't quite know what this picture will look like a year from now.

I keep hearing reports that adverse effects from the vaccines are being suppressed and kept hush-hush. Reports to the VAERS system are not being filled out, and even then, with the limited data available, the adverse events from COVID-19 vaccines seem to greatly outstrip vaccines for other diseases in previous years. The anecdotal reports are appalling. One news station asked people what their experiences were with COVID-19, and if they'd lost family from the virus. They instead got replies from hundreds of people claiming their family members were injured by the vaccines.

Lots and lots of people are very scared.
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October 03, 2021, 04:07:47 AM
 #122

Okay, so you want to put electrodes in the brain. How do you power them if there are no wires? Simple. You use nanoparticles that self-assemble into antennas and circuits capable of harvesting RF and outputting a mild electric current.

How do you titrate the dosage to each person's brain? Simple. You use a source that can steer different beams of different dosages to different people's brains. 5G base stations are phased-array antennas with beamforming and MIMO. Problem solved.

Antenna size is directly correlated to wavelength. Minimum antenna size for 5G signal is ~3mm. AFAIK there are some tricks to reduce that slightly, perhaps to 2mm. That's still 4-5 orders of magnitude beyond what is considered nanotechnology. Not gonna fit through the needle either.

None of this stuff is technologically infeasible. At all.

Yeah... it is technologically infeasible. The fact that you talk a lot about remote mind control via nanoparticles but provide links to much more limited experiments with electrodes should be a hint that you're not exactly honest with that statement.

Then there is another huge leap between technological feasibility and the ability to do it covertly at scale.

How many nano particles do you need to align to reach 2mm? Have you seen what's in the "inject-able fuilds" when it dries, specially what's rising up from it?

Remember Calvin from the movie "life"?



Personally, I don't know in which movie we are : "Alien: Covenant", "5th wave" or "Life"...

However I had one original though...

okay let's say that spartacus is our enemy (it would be surprising that he isn't btw).

So from seeking vengeance/retribution on those responsible from covid release, or denial of treatments leading to a lot of death, he tries to move us to his BCI utopia "to protect us".

and what's fun, is that even to defeat the BCI slavemasters, it is necessary to rewind the crime trails... starting with Tuskegee crime against Mankind :

https://www.banned.video/watch?id=6158665d439857296fc8b06d

Otherwise, I guess, it's the modus operandi of so called democracies, at each new regime, hide the deeds of the previous ones...

until it's not more a closet needed for the squeletons, but a whole necropolis...

When the people of the world will get that covid was intentionally released to frame china, steal the election from trump, assure massive bail outs and foster the forced vaccination agendas...they will forget, like 911, wmds in irak, uss liberty or pedogate.
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October 03, 2021, 04:50:03 AM
Merited by Tash (3)
 #123

...
Antenna size is directly correlated to wavelength. Minimum antenna size for 5G signal is ~3mm. AFAIK there are some tricks to reduce that slightly, perhaps to 2mm. That's still 4-5 orders of magnitude beyond what is considered nanotechnology. Not gonna fit through the needle either.

How many nano particles do you need to align to reach 2mm? ...

They guy is a dope.  He thinks that nobody can figure out that a variety of antenna designs work well even being less than a wavelength in size.  Else an AM radio would have to be 300 meters long.


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October 03, 2021, 05:15:32 AM
 #124

I had my last post deleted but to remain on topic and within my remit but I will say that it is too late to stop what is about to be rolled out soooooooon but you do have a choice. Participate and live a reasonably comfortable life albeit subject to your benevolent academic overlords and central planners or refuse to participate and life will become difficult. I would personally choose the latter. Life is not too bad as an outcast Grin

And "the Matrix 4" is about to be released... Do you think it is a coincidence?



An earlier version of the "vaccine"


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October 03, 2021, 06:32:37 AM
Merited by mindrust (1)
 #125


The paid shills will correct what the magnets missed
https://ibb.co/JRxztvh

Spartacus is reeling them in like a fish.  They put the top guy on the Oilyeo personna which has a ton of groupies who bought the 'I'm a doctor' shtick, then Spars plays Mr. nice-guy and proceeds to hammer his balls flat.  But first a phase of getting them to lay their nads the block and getting the mallet handy.

Currently both are playing a game of 'maybe the corp/gov malfeasance just greater-good subterfuge for the benefit of the herd.'  Nobody thinking person can actually believe that when the situation is looked at in totality, so the trick is to get more people to actually look.  I dare say that the sleeze-balls who commisioned the Oilyeo side are looking frantically about now.  Hopefully Spars has his op-sec wired tight.


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October 03, 2021, 06:41:06 AM
Last edit: October 03, 2021, 12:32:04 PM by Tash
 #126

...
Antenna size is directly correlated to wavelength. Minimum antenna size for 5G signal is ~3mm. AFAIK there are some tricks to reduce that slightly, perhaps to 2mm. That's still 4-5 orders of magnitude beyond what is considered nanotechnology. Not gonna fit through the needle either.

How many nano particles do you need to align to reach 2mm? ...

They guy is a dope.  He thinks that nobody can figure out that a variety of antenna designs work well even being less than a wavelength in size.  Else an AM radio would have to be 300 meters long.



suchdope

5th generation mobile network (or any other) is not limited to single wavelenght. Different carrier use differant signal depenting on target audience, longer wavelenght more coverage, higher pulserate need more towers and more susceptible to weather....
60Ghz (5mm) is open usage anyone can use same as 2.4Ghz (Router, bluetooth, wireless headphones....)
T-mobile 600Mhz and 2.5ghz
Sprint 800Mhz, 1.9Ghz, and 2.5Ghz
Verizon 28ghz and 39ghz
Corresponding full, 1/2 or 1/4 wavelenghts (1/4 wavelenghts is over 50 years old, what can be done this days?)
https://www.omnicalculator.com/physics/dipole

Pigeon "freezes" mid air next to 5G tower
https://twitter.com/i/status/1281355107309936640

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October 03, 2021, 07:03:27 AM
 #127

Spartacus is reeling them in like a fish. 

To be clear here, I've not gone too deep into the Spartacus Letter. Only about page 3 of the PDF, and the last highlighted term I had is "multinuclear giant cells" that I was off on a tangent learning about - something related/similar to bone marrow or some shit? I dunno, anyway...

I understand it starts getting into more conspiracy minded talk later on in the paper, and honestly, my eyes may begin to roll at speculation or theoretical postulations, but in speaking to just the beginnings of the paper - at least - I can say it's been a fascinating, plausible, and accurate read so far, describing how COVID19 affects human physiology.

I'm skeptical AF, and internally am all like "Yeah, right... The Spartacus Letter author is actively interacting with our little corner of the internet, but I've seen stranger things happen, and TBH, this is the best LARP I've seen so far, so I'll pay peripheral attention to it while I do a deep-dive of the letter, cross-referencing the research independent of their footnotes and citations" sorta deal.

Back to metaphorical popcorn.
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October 03, 2021, 07:31:31 AM
 #128

What I don't get is why we aren't seeing any results for many of these antioxidant trials.
We see this kind of thing not infrequently in medicine, and even more so in critical care. Drugs or treatments which show promising results in vitro, show promising results in rodent models, maybe even show promising results in healthy volunteers, but when we apply them to critically ill patients, they either don't work or even make things worse.

Says Dr. suchmoon, citing lab-rats incooporated.
Honey, all of your past & future arguments, halt and sum up, in the “get your vaccine” mission, you’re so eager to promote.
In contrast, Spartacus stands for the DO YOUR OWN RESEARCH motto.

I’d like to keep my job, can I?
I’d like to travel the world, can I?
I’d like not to be told what to do, can I?

If you get stopped speeding, you face the consequences.
If you kill someone, you also face the consequences.
And now, in the COV era, why do I have to face to consequences for doing absolutely nothing at all?
“Public safety”? Wicked! Tongue

I have come here to chew bubblegum and kick ass ... and I'm all out of bubblegum.
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October 03, 2021, 07:45:54 AM
 #129

Spartacus is reeling them in like a fish. 

To be clear here, I've not gone too deep into the Spartacus Letter. Only about page 3 of the PDF, and the last highlighted term I had is "multinuclear giant cells" that I was off on a tangent learning about - something related/similar to bone marrow or some shit? I dunno, anyway...
...

This is a very fascinating aspect of the whole game-board as it is unfolding.

It is not normal for two cells to join into one bigger cell.  Nor is it a common need most of the time.  Most of the time it would just be a problem and cell membranes are evolved to avoid this happening.

Placental mammals (as opposed to marsupial mammals such as opossum or kangaroo) need to do it in a specialized condition.  Pregnancy.  It is how the placenta begins to form.  It is thought that at some point in the very distant past, a germ cell (egg or sperm) was attacked by a virus which had expressed an interesting protein which provoked this fusion.  Instead of being killed by the virus, the germ cell stole the code...and that's why we humans, and most other mammals, walk the earth today.

This protein?  If you guessed 'spike protein family', congratulations!  That could help explain the seemingly intense interest (and money) dumped into study of the substance within the corp/gov scientific circles.  And the various splicing that appears to have been happening in the various labs working on 'bat coronavirus'.

Wouldn't you know it, but a gene therapy which programmed cells to produce and pump out spike proteins was ready to go just a few days after them chinks made SARS-cov-2 by eating them bats.  It's a miracle!

A potential problem (or solution depending on one's point of view) with making people allergic to spike protein is that you might make them allergic to a placenta when it's needed due to similar proteins being involved with both.  This is quite aside from the ADE risk which is being much discussed lately.  The jargon 'unsafe epitopes' relates to this potential risk.


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October 03, 2021, 08:31:47 AM
 #130

A potential problem (or solution depending on one's point of view) with making people allergic to spike protein is that you might make them allergic to a placenta when it's needed due to similar proteins being involved with both.

So yeah. There's this film I watched once named "Children of Men". I should probably go watch it again in the post-COVID19 world, come to think of it...

https://www.rottentomatoes.com/m/children_of_men
https://www.imdb.com/title/tt0206634/
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October 03, 2021, 08:55:30 AM
 #131

A potential problem (or solution depending on one's point of view) with making people allergic to spike protein is that you might make them allergic to a placenta when it's needed due to similar proteins being involved with both.

So yeah. There's this film I watched once named "Children of Men". I should probably go watch it again in the post-COVID19 world, come to think of it...

https://www.rottentomatoes.com/m/children_of_men
https://www.imdb.com/title/tt0206634/

Sure.  Just note that the people who write and act in these things are compensated well in excess of their counterparts at JIDF and suchlike.  But ultimately from the same endless well of money though.

I don't watch movies, TV, Radio, or broadcast media in real-time.  But that's just me.


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October 03, 2021, 11:57:55 AM
Last edit: October 03, 2021, 12:41:48 PM by B1tUnl0ck3r
 #132

By all hells watch this : Dr. Carrie Madej joined Stew Peters today and appeared obviously shook by what she had seen after examining Moderna and J&J "vaccine" vials.
4:30 https://www.brighteon.com/aa151644-a720-4842-8116-c016ffc64c58

omfg... self assembling structures... so for the BCI it would work to reach the 2mm length... at 60ghz what's the minimal length of the antenna? and would it be possible without even using self replication/assembling antenna to just use the own body as an antenna? I mean to use bones or structures in the corpse as length amplifier to achieve reception of commands?

now pics...

ommmmggggg..... alien covenant / life ///// end of time / give me my crysis suit NOOOOOOOOOOOOOOOOOOOWWWWWWWWWWWW

edit that's what she fucking saw at 400x zoom (because muppets say magnification and fuck muppets).



self assembling antenna

and now... omg omg omg omg omg omg omg omg omg... save us ! death come (aka salvation with death)



it's beyond words...

edit 2 : then on the discussion we can see we have 2 camps : A) the autistic crews, who are self checking cross referencing the whole (good works kids, keep doing and please a short summary on the finding) and team B) we fucking know it's true, we saw all the interviews of all the banned docs and more, and we are on the BCI aspect of it... omg omg omg...

edit 3 reply to the mongoes.

...
Antenna size is directly correlated to wavelength. Minimum antenna size for 5G signal is ~3mm. AFAIK there are some tricks to reduce that slightly, perhaps to 2mm. That's still 4-5 orders of magnitude beyond what is considered nanotechnology. Not gonna fit through the needle either.

How many nano particles do you need to align to reach 2mm? ...

They guy is a dope.  He thinks that nobody can figure out that a variety of antenna designs work well even being less than a wavelength in size.  Else an AM radio would have to be 300 meters long.



you genius... tell me what is the minimal length at 60ghz... that's it... simple: physically possible or not... btw you should really watch dr zelenko on alexjones show, very informative, I guess on Chabad/theblackhats... it's not what you believe in... in short only 5% of the jews reached the promised land ( 80% stayed in slavery and 15% had problems in the tribulations (desert walk)... and see the part with "jews are people"... simple, he is doctor, he understand... doctor is insulting to him... healther would be more appropriate... love it. btw how do people get access to knowledge? otherwise, full agreement (rare).


And "the Matrix 4" is about to be released... Do you think it is a coincidence?

An earlier version of the "vaccine"


nope, predictive programming, however I don't believe the western pedo aristocrats seek to merge with the machine, more to use us or trap us in it... they are the enemies of mankind.


The paid shills will correct what the magnets missed
https://ibb.co/JRxztvh

Spartacus is reeling them in like a fish.  They put the top guy on the Oilyeo personna which has a ton of groupies who bought the 'I'm a doctor' shtick, then Spars plays Mr. nice-guy and proceeds to hammer his balls flat.  But first a phase of getting them to lay their nads the block and getting the mallet handy.

Currently both are playing a game of 'maybe the corp/gov malfeasance just greater-good subterfuge for the benefit of the herd.'  Nobody thinking person can actually believe that when the situation is looked at in totality, so the trick is to get more people to actually look.  I dare say that the sleeze-balls who commisioned the Oilyeo side are looking frantically about now.  Hopefully Spars has his op-sec wired tight.



I agree... oeleo dipshit of the state, die (aka use mute). next problem.

...
Antenna size is directly correlated to wavelength. Minimum antenna size for 5G signal is ~3mm. AFAIK there are some tricks to reduce that slightly, perhaps to 2mm. That's still 4-5 orders of magnitude beyond what is considered nanotechnology. Not gonna fit through the needle either.

How many nano particles do you need to align to reach 2mm? ...

They guy is a dope.  He thinks that nobody can figure out that a variety of antenna designs work well even being less than a wavelength in size.  Else an AM radio would have to be 300 meters long.



suchdope

5th generation mobile network (or any other) is not limited to single wavelenght. Different carrier use differant signal depenting on target audience, longer wavelenght more coverage, higher pulserate need more towers and more susceptible to weather....
60Ghz (5mm) is open usage anyone can use same as 2.4Ghz (Router, bluetooth, wireless headphones....)
T-mobile 600Mhz and 2.5ghz
Sprint 800Mhz, 1.9Ghz, and 2.5Ghz
Verizon 28ghz and 39ghz
Corresponding full, 1/2 or 1/4 wavelenghts (what fraction can be done this days?)
https://www.omnicalculator.com/physics/dipole

Pigeon "freezes" mid air next to 5G tower
https://twitter.com/i/status/1281355107309936640

we dont' give a fuck about the legal (they rape kids on islands don't you get it mofos braindead washed out ?)... it's more what's PHYSICALLY possible, aka SCIENCE... or more powerful : APPLIED SCIENCE.

I saw the bees die off... massacre incoming... brainless morons bailed on fake fiats leading industries protected by their pedos covenants... horror...

Spartacus is reeling them in like a fish.

To be clear here, I've not gone too deep into the Spartacus Letter. Only about page 3 of the PDF, and the last highlighted term I had is "multinuclear giant cells" that I was off on a tangent learning about - something related/similar to bone marrow or some shit? I dunno, anyway...

I understand it starts getting into more conspiracy minded talk later on in the paper, and honestly, my eyes may begin to roll at speculation or theoretical postulations, but in speaking to just the beginnings of the paper - at least - I can say it's been a fascinating, plausible, and accurate read so far, describing how COVID19 affects human physiology.

I'm skeptical AF, and internally am all like "Yeah, right... The Spartacus Letter author is actively interacting with our little corner of the internet, but I've seen stranger things happen, and TBH, this is the best LARP I've seen so far, so I'll pay peripheral attention to it while I do a deep-dive of the letter, cross-referencing the research independent of their footnotes and citations" sorta deal.

Back to metaphorical popcorn.

keep going like this and you will be unbanned mofo !

Spartacus is reeling them in like a fish.

To be clear here, I've not gone too deep into the Spartacus Letter. Only about page 3 of the PDF, and the last highlighted term I had is "multinuclear giant cells" that I was off on a tangent learning about - something related/similar to bone marrow or some shit? I dunno, anyway...
...

This is a very fascinating aspect of the whole game-board as it is unfolding.

It is not normal for two cells to join into one bigger cell.  Nor is it a common need most of the time.  Most of the time it would just be a problem and cell membranes are evolved to avoid this happening.

Placental mammals (as opposed to marsupial mammals such as opossum or kangaroo) need to do it in a specialized condition.  Pregnancy.  It is how the placenta begins to form.  It is thought that at some point in the very distant past, a germ cell (egg or sperm) was attacked by a virus which had expressed an interesting protein which provoked this fusion.  Instead of being killed by the virus, the germ cell stole the code...and that's why we humans, and most other mammals, walk the earth today.

This protein?  If you guessed 'spike protein family', congratulations!  That could help explain the seemingly intense interest (and money) dumped into study of the substance within the corp/gov scientific circles.  And the various splicing that appears to have been happening in the various labs working on 'bat coronavirus'.

Wouldn't you know it, but a gene therapy which programmed cells to produce and pump out spike proteins was ready to go just a few days after them chinks made SARS-cov-2 by eating them bats.  It's a miracle!

A potential problem (or solution depending on one's point of view) with making people allergic to spike protein is that you might make them allergic to a placenta when it's needed due to similar proteins being involved with both.  This is quite aside from the ADE risk which is being much discussed lately.  The jargon 'unsafe epitopes' relates to this potential risk.



you could have at least named the proteins in the placenta that the jab targets... I don't remember the name... leading to the bleeding in females... (cyastine??)

A potential problem (or solution depending on one's point of view) with making people allergic to spike protein is that you might make them allergic to a placenta when it's needed due to similar proteins being involved with both.

So yeah. There's this film I watched once named "Children of Men". I should probably go watch it again in the post-COVID19 world, come to think of it...

https://www.rottentomatoes.com/m/children_of_men
https://www.imdb.com/title/tt0206634/

that's absolute gay... watch life and alien covenant... that's where we are with a dose of matrix... that's it... 5th wave is way too kind... and there is a movie with aliens in chirak hiding in a bunker that people seek to nuke... quite cool, don't have the name...

A potential problem (or solution depending on one's point of view) with making people allergic to spike protein is that you might make them allergic to a placenta when it's needed due to similar proteins being involved with both.

So yeah. There's this film I watched once named "Children of Men". I should probably go watch it again in the post-COVID19 world, come to think of it...

https://www.rottentomatoes.com/m/children_of_men
https://www.imdb.com/title/tt0206634/

Sure.  Just note that the people who write and act in these things are compensated well in excess of their counterparts at JIDF and suchlike.  But ultimately from the same endless well of money though.

I don't watch movies, TV, Radio, or broadcast media in real-time.  But that's just me.



banning all this for one life is a big time gain ! tv : TimeVampire, and they are the enemies... will just be fun to watch them when they will be at the stage of bagdad bob (aka with storm troopers entering their hive and killing them live on stream... that's the fun part coming, necessary and I hope).

-------------------

CONCLUSION : THE GOV AND ITS OPERATIVES HAVE TO BE SEEN AS THE ENEMIES.



edit 4 : real Combat AI having survived DOD elimination attempts doesn't need anything to interface... too low tech... ahahah.

When the people of the world will get that covid was intentionally released to frame china, steal the election from trump, assure massive bail outs and foster the forced vaccination agendas...they will forget, like 911, wmds in irak, uss liberty or pedogate.
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October 03, 2021, 12:38:40 PM
 #133

I don't watch movies, TV, Radio, or broadcast media in real-time.  But that's just me.

Allegories are insightful to any sentient species, but that's just me.
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October 03, 2021, 12:47:54 PM
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Well, you're absolutely right. Something that seems promising in vitro is not always useful in vivo. A drug that works great on a cell culture may never even reach the cells in question when applied to a living body, which is basically a giant maze.

However, that's not what I meant. Look at those links I posted again. Many trials have failed to post any results at all, even over a year after their completion. Not positive, not negative. Nothing. No data. That's so frustrating to see.
A number of possibilities. Could be that they are still writing up the data, but since these trials you linked are generally very small numbers of patients (<100), it shouldn't take them long to analyze. Could be that they failed somewhere along the way with recruitment, or administrating the intervention, or maintaining the blindedness, etc. Could be that their results were negative and so they just gave up and didn't bother to write them up.

Isn't there anything that can be done in terms of surveillance and early treatment before they become critically hypoxic?
Vaccination.

If you get as far as the hospital with COVID then you'll get all the treatments we have good evidence for which I outlined above - dexamethasone, remdesivir, tocilizumab, NIV - all with the aim to prevent intubation.

I have seen so many instances where people go over the topic of COVID-19 death certificates, hear that a PE, stroke, or myocardial infarction killed someone who was sick with COVID-19, and then angrily grumble something about how hospitals are inflating COVID-19 numbers by designating deaths from infarcts as COVID deaths.
Tell that to your fellow anti-vaxxers. They are the ones perpetuating this nonsense.

I know they're trying to prevent a panic, but at this stage, more information is better. It has to be.
We give out plenty of information, barn door irrefutable information, and still some people deny it. People look at the death rates and falsely claim they are being inflated, as you just pointed out. People deny that hospitals are full, when we've literally taken over entire floors to turn them to expanded ICUs. People don't even think COVID is real, despite it being isolated hundreds of thousands of times and killing millions. Explaining the intricacies of COVID pneumonia or multi-organ failure isn't going to change the mind of these people. Indeed, as evidenced by this very thread, if you try to do so you get simply get insulted and told to go die. Roll Eyes

Lots and lots of people are very scared.
Absolutely. And feeding them provable lies about how our single greatest weapon in the fight against COVID is gene therapy or mind control or nanotech or any other nonsense is the root of a lot of that fear.
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October 03, 2021, 01:03:52 PM
 #135

They guy is a dope.  He thinks that nobody can figure out that a variety of antenna designs work well even being less than a wavelength in size.  Else an AM radio would have to be 300 meters long.

Corresponding full, 1/2 or 1/4 wavelenghts (1/4 wavelenghts is over 50 years old, what can be done this days?)

Right, we're injected with a bunch of loop antennas Roll Eyes

How about you two stop dicking around and show us the design of the nano antenna that definitely exists in the vaccine and can extract usable amounts of power from the 5G waves at 100m+ from the transmitter inside a building and inside someone's skull (assuming the subject is not wearing at tinfoil hat).


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October 03, 2021, 01:04:05 PM
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We give out plenty of information, barn door irrefutable information, and still some people deny it.

Plenty of logical fallacies, pharmaceutical market-grade gaslighting, and uninformed consent, too.

"We want you to get the experimental gene therapy because we care about you."

It's terrifyingly dystopian.
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October 03, 2021, 01:46:26 PM
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It is neither experimental nor gene therapy.
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October 03, 2021, 03:03:45 PM
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It is neither experimental nor gene therapy.

Could you please point me to long-term clinical studies?

I mean, what else do you call a nanoparticle changing the way proteins are expressed, if not a gene therapy, because I'll tell you hwat - that ain't no vakseen I ever herd of...

kthx.
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 #139

A number of possibilities. Could be that they are still writing up the data, but since these trials you linked are generally very small numbers of patients (<100), it shouldn't take them long to analyze. Could be that they failed somewhere along the way with recruitment, or administrating the intervention, or maintaining the blindedness, etc. Could be that their results were negative and so they just gave up and didn't bother to write them up.

That's another thing. There are many scattershot, low-quality, underpowered studies that are recruiting like 20 people to test a drug, and 20 people for the control group.

If there are so many patients, why are the sample sizes so small? If our hospitals are flooded with dying people, as you say, then why can't they enroll more than a handful at a time? Surely, there should be a surfeit of people who could participate in these trials.

Something here does not add up.

If you get as far as the hospital with COVID then you'll get all the treatments we have good evidence for which I outlined above - dexamethasone, remdesivir, tocilizumab, NIV - all with the aim to prevent intubation.

Antivirals pretty much don't work unless they're taken as post-exposure or pre-exposure prophylaxis. This can be shown by examining the clinical course of the virus.

https://www.mdpi.com/1999-4915/13/6/963/htm

https://curriculum.covidstudentresponse.org/module-1-from-bench-to-bedside/management-of-covid-19

At the onset of the ARDS/pro-inflammatory phase, the viral load has actually reached a nadir in most patients. There is no virus left to prevent the replication of.

https://www.forbes.com/sites/jvchamary/2021/01/31/remdesivir-covid-coronavirus/?sh=aaaa7bd66c27

I hate having to repeat myself, but many, many studies cited by the media as proof of the ineffectiveness of antivirals were studies that recruited severely ill, hospitalized people. Oxford's RECOVERY study, for instance. That was pretty much people who had already reached day 10 post-exposure and were already suffering from hyperinflammation. Remdesivir does nothing, aside from putting additional strain on the liver, with a virus that already causes abnormal AST/ALT readings. That's a contraindication.

https://pubmed.ncbi.nlm.nih.gov/32702162/

https://pubmed.ncbi.nlm.nih.gov/33947196/

The treatment of COVID-19 patients is time-sensitive. These patients need early, proactive interventions to prevent them from progressing to sepsis.

Tell that to your fellow anti-vaxxers. They are the ones perpetuating this nonsense.

Many of them are believers of Antoine Béchamp who think that germ theory is actually wrong and viruses do not cause disease. It is difficult to warn people about a virus and its properties when the fundamental knowledge is so lacking. I do indeed blame the government and the rapidly declining quality of public education for that. People are wearing scientific ignorance as a badge of pride, because science has become so politicized. It shouldn't be. Knowledge is power, and science is merely a means of obtaining knowledge.

I hold both the worship of science and the hatred of science in equal contempt. The left trying to turn PhDs into clergymen is as appalling as the right rejecting science entirely. It doesn't matter if someone is right-wing or left-wing or whatever. They need to know that science is a valuable tool available to all, and it should not be perceived merely as an avenue of propaganda.

Granted, institutional science is becoming increasingly corrupted by special interests with questionable agendas, and science publishers are some of the most corrupt sons of bitches around. However, that doesn't reflect poorly on science as a concept. It reflects poorly on our institutions.

We give out plenty of information, barn door irrefutable information, and still some people deny it. People look at the death rates and falsely claim they are being inflated, as you just pointed out. People deny that hospitals are full, when we've literally taken over entire floors to turn them to expanded ICUs. People don't even think COVID is real, despite it being isolated hundreds of thousands of times and killing millions. Explaining the intricacies of COVID pneumonia or multi-organ failure isn't going to change the mind of these people. Indeed, as evidenced by this very thread, if you try to do so you get simply get insulted and told to go die.

COVID-19 can, in many circumstances, be a lethal, SARS-like disease with some rather extraordinary complications. It can also lead to disturbing sequelae, like ME/CFS, pulmonary fibrosis, and neurological issues. I don't doubt that at all. In fact, I encourage anyone who is still on the fence about COVID-19's pathology to do their own investigations and go over the primary sources to the best of their ability.

One of the best starting points is to approach the virus as a vascular endotheliitis that causes severe oxidative stress and iron metabolism dysregulation, leading to sepsis and lipid peroxidation in the pulmonary vasculature.

https://academic.oup.com/eurheartj/article/41/32/3038/5901158#208335511

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7757048/

https://www.nature.com/articles/s41420-020-00369-w

Lipid peroxidation - the oxidation or "bleaching" of fats in the body - is nasty process. See the following:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3075542/

COVID-19 patients have noticeable ferroptosis signatures in their tissues, Anti-PL and Anti-CL antibodies, high serum nitrotyrosine, and low nitric oxide bioavailability. All of these things point to the same thing; a pathological state dominated by extreme oxidative stress.

Once lipid hydroperoxides begin to form, they recursively increase inflammation by triggering pattern recognition receptors and attracting autoantibodies. They take forever to detoxify, too, so if you're going to try and dose people with antioxidants, NADPH oxidase inhibitors, calcium channel blockers, Vitamin D, selenium, NAC, Nrf2 activators, whatever, it has to be early. Very early on. Before the disease has progressed to hyperinflammation.

However, as I said before, I doubt there is a magic pill that prevents this. The key thing is for blood vessel physiology to be improved by a healthy lifestyle. The government guidelines should be for people to stay active, stay healthy, diet correctly, and lower their BMI if they're overweight or obese. This would, in the long run, save many lives, because the evidence for COVID-19 causing greater mortality in people with a higher body-mass index (likely due to pre-existing endothelial dysfunction) is overwhelming.

What are they doing instead? They're forcing people to stay indoors. Encouraging them to become fat and sedentary and sun-deprived. All of these things make COVID-19 measurably worse.

That scientist in Pittsburgh who was killed in a murder-suicide was an expert in iron metabolism and redox biology.

Bing Liu Knew.

Absolutely. And feeding them provable lies about how our single greatest weapon in the fight against COVID is gene therapy or mind control or nanotech or any other nonsense is the root of a lot of that fear.

I have never, in my entire lifetime, seen a vaccination campaign involving threats of martial law and firings for noncompliance. Given that the IFR of COVID-19 is relatively low in absolute terms, not even near to approaching the lethality of something like Smallpox (which people lived with day in, day out, without any economic disruptions whatsoever, despite the gruesome toll in lives it took every year), the lockdowns and the strange behavior of our governments makes no sense unless there is an ulterior motive.

Despite being morally abominable, mind control and depopulation are perfectly sensible motives. They "fit" neatly in the hole left behind by the absence of other explanations.

The thing about super high-frequency RF is that RF in the tens of GHz is stopped in the skin, and in the THz range, it's stopped by atmosphere. That's how the Raytheon ADS maser works; water molecules in the skin rapidly heat and produce a burning sensation.

There are, however, ways of getting tiny nanoparticles to receive lower frequencies than normal. One is plasmonic subwavelength waveguides.

https://www.hindawi.com/journals/ijo/2012/258013/

http://ham.seas.harvard.edu/upload/papers/2012/ultra.pdf

The frequencies received by these are still too high.

Another, simpler way is self-assembling materials (i.e. electrostatic attraction, hydrophilic-hydrophobic attraction and repulsion, etc.) that make larger antennas in the body that can receive longer wavelengths.

https://www.orwell.city/2021/06/graphene-oxide-in-vaccination-vials.html

https://odysee.com/@Evolutionary_Life_Video_Archive:3/germanvaxxnanoparticlecovid19:b

People have the wrong idea about mind control. This isn't something as sophisticated as remote-piloting someone's limbs from afar, like in the movies. It's far more crude than that. If you had the ability to remotely stimulate the reward center of the brain, like they do with DBS electrodes on alcoholics, you could profoundly affect mood. The results, on a societal scale, would be undeniable.

For the Human Cattle Ranchers, there is a motive; ending populism and nativism, of course. Why would they do this? Simple. It would depress wages and put more money in their pockets if working-class people were cybernetically pacified to the point of emotionally accepting their status as serfs and giving up any ambitions of climbing any higher than that. It would also be great for the environment. Someone who is perpetually satisfied by a neural implant has no need of rich food or a vacation to Cancun, or other luxuries. That makes their carbon footprint smaller. It also makes them less desirous of sexual intercourse, which helps with overpopulation and tamps down on people's dissatisfaction with their inability to buy houses and start families.

The result? Instead of the default state of man in first-world countries being someone who demands a 3500+ square foot McMansion and a three-car garage, you now have a man who will happily live in a sub-50-square-foot prison cell eating locusts and mealworms for breakfast and then going to work and being berated by their boss while sitting in a cubicle and responding to memos for very little pay. He would never even consider rebellion against this state of affairs. He has been pushed off the hedonism treadmill and onto the floor.

So many effects, and all you have to do is pump fake reward into someone's reward center. Primitive, crude, and most of all, effective.

And, of course, if the vaccine does turn out to be a lethal depopulation kill shot in the long-term, such pacification would be absolutely necessary to keep people from rising up when they see their friends and neighbors become infertile and/or die from the effects.

You insist that the vaccine is beneficial and will reduce morbidity and mortality in the long run. Initially, in the short-term, this may have been true. However, newer data paints a bleak picture.

https://dreddymd.com/2021/10/02/ai-powered-dod-data-analysis-program-project-salus-shows-ade-accelerating-fully-vaccinated/

https://www.brighteon.com/c3c52dd7-7db9-4e1c-b386-58b9a6c97f5b

https://www.npr.org/sections/goatsandsoda/2021/08/20/1029628471/highly-vaccinated-israel-is-seeing-a-dramatic-surge-in-new-covid-cases-heres-why

https://www.visiontimes.com/2021/09/14/pfizer-27x-symptomatic-covid-break-through-natural-immunity.html

The breakthrough infections are getting worse and worse. How long before these antibodies flip to being non-neutralizing, and ADE (and with it, higher viral loads, greater rates of hospitalization, and higher morbidity) rears its ugly head?

The clock is ticking.

It is neither experimental nor gene therapy.

The Moderna and Pfizer COVID-19 vaccines are the first-ever products to use mRNA technology, and they were adopted under accelerated trials. In Moderna's case, it's their first-ever commercial product. That should be considered a major red flag, however, the media and politicians are pushing vaccination as the way to end the pandemic. Except COVID-19 cannot be stopped. It is endemic, and it has animal reservoirs. You can't vaccinate it away any more than you can vaccinate away the flu or the common cold. They are being highly disingenuous, pushing medical countermeasures on people who don't want them.

Furthermore, it is entirely possible for mRNA to be integrated into one's genome by endogenous reverse transcription.

https://pubmed.ncbi.nlm.nih.gov/33330870/

If, for some reason, the vaccine mRNA does become integrated into the host genome, that is a gene delivery system. That is, gene therapy.
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October 03, 2021, 04:33:34 PM
Last edit: October 03, 2021, 04:54:26 PM by ICENI_Spartacus
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 #140

ICENI_Spartacus first let me say - thank you for existing. I imagine it must be very hard and tiring especially psychologically to go all in against the powers, against the narrative, and against the everyday normal people that you're trying to save but they don't realise it and attack you (kinda reacting like our own immune systems when they've been cheated and modified by the virus)... collecting information piece by piece like a bee and knowing you will get no reward or recognition even if you succeed in saving us - you're a special person driven by duty and thank God there are people like you. To stay sane and carefully analyse this weird horrific puzzle and to try and make sense out of it. Please don't stop. Even if you are on a wrong path sometimes - don't ever quit or take it as a discouragement as I believe you will eventually get your eureca moment and crack this all and for once. You are important as you have many of the events in your head, and many of the public information since COVID's emergence and in case this public info goes missing online (which is actually happening gradually and with time) - you will still be able to connect the dotts once you gather enough info or logical proof for what's happening. It doesn't matter if you're 1 person or a huge team - this Spartacus letter approach is working and getting to people so you're doing something - very right.

After seeing what the powers-that-be are doing to people, I decided that resistance was a matter of principles. It doesn't matter what happens to me. Not really. So long as the people who did this to us are made to suffer for it, their reputations dragged through the mud, and so long as these patients start getting treatments that actually work, all is well.

Saying all this I want to ask you the following, if you allow me:

- What's your option on China and their vaccines? Why did China choose to go to the inactivated variant of a vaccine? For me - this is very interesting. US also has been working on inactivated virus vaccine which most definitely won't be used for the masses (perhaps only those high importance will take it). Is China really trying to protect their population from COVID which might have essentially been planned and executed as a bioweapon against them and against the rest of the world (killing China and enslaving the rest of the world). Perhaps they didn't expect China to close down so aggressively and to stop the COVID spread and come up with a vaccine to save themselves. If China were in cahoots with the planners why would they release it on themselves and why would they go the inactivated vaccine route which is less technological (they don't have mRNA technology) and perhaps... actually effective? From my perspective even if China did release the virus themselves to the world they still need to protect themselves with a working vaccine, so both situations require them to come up with a real vaccine... Otherwise why not just use mRNA like everybody else? Geopolitically if this is a war between Anglo-Saxons/NATO against the rest of the world (undeveloped nations who catch up economically and will want their share on global stage) then it makes some sense to look at it at this angle. There is no doubt about the ambitions of some people who want the One World Government but is this truly possible and achievable taking in mind there are also other people (Putin, Maduro, Duterte, Xi Jinping) wanting control of their own countries just as bad. Those people are as megalomaniacal as well - let's not forget that. As much as powerful and rich people align in philosophy - they don't like to share the bone they're holding. And if Macron, Boris Johnson, Biden, Ursula and others of this kind are perceived as tyrants or people of great power nowadays - they've climbed the power ladder rather easily by bending knee in front of their masters and aren't the true masters. So it's expected that they will just follow the agendas and the orders. But this can't be said about Putin, Maduro, Duterte, Xi Jinping etc. Their power ladder was climbed in a totally different way. Do any of us know just how many people has Maduro killed to get on top? Those people have truly earned their power. And to think they will just hand it down to Anglo-Saxons/NATO/ or... Schwab. Just because they have the same hunger to oppress people... well they already do this. If anything - democracies are scary because they allow free speech. And Venezuela, Russia, China aren't quite the democracies and never actually were even close to that. So what is your geopolitical stance and your China vaccine stance? What happens in the body when Sinovac or Sinopharm is used? What does the inactivated COVID do? I think we can pretty much disregard vaccine side effects as a proof of bad intentions as if you think logically... if their intention is to control populations by the vaccine, then the COVID itself will be the population reduction mechanism and the vaccine side effects are just... vaccine side effects (also why would they scare population by side effects like it's happening now... they want the population to actually take it... I think they just screwed up "Windows BSOD" style...) because all vaccines have them - side effects, especially the non-tested ones, and the rushed ones to the market. Also what is your proposed treatment/prevention protocol for coagulopathy?

I know that whole SARS vaccines have not worked well in the past. They induced immune sensitization.

https://pubmed.ncbi.nlm.nih.gov/22536382/

Consider this: why are China vaccinating old people last? The highest-risk group?

https://www.scmp.com/news/china/science/article/3127484/china-moves-elderly-further-covid-19-vaccine-queue

China has a demographic problem. A big one. Too many old people, and too many men. The one-child policy really screwed them up. They want more kids to man the factories, and less old people straining the safety nets.

US/NATO vs China/Russia is a giant red herring. The mere fact that the virus was created in a Chinese lab with funding from our own NIH, DTRA, and USAID shows this to be the case. What's actually happening is that the Human Cattle Ranchers (the HCRs, if you will) are playing kingmaker, trying to select some country other than the United States to be the head of the New World Order. The way they are accomplishing this is by the controlled demolition of the entire Anglosphere.

WWIII is presently happening. It is not a war between world powers. That's a distraction. The HCRs do not believe in nation-states; the idea of politics being a team sport with nations as the teams is an illusion for the little people. There is only one single, global, extractive enterprise, which all nations play a part in. This war consists of biowarfare and information warfare waged by governments against their own citizens, to stem the tide of overpopulation and prevent resource wars in the future. The combatants are not wearing uniforms and we are not being paid a salary to fight. In other words, we are being expected to react to psyops by volunteering our valuable time.

600,000 deaths in a year, most of them older people on the verge of death anyway, with many comorbidites, is not something that you would notice unless the media is blasting it in your ears 24/7. Would you know about the millions who have died each and every year for the past several decades of preventable illnesses if they didn't tell you? No. In China, where they have a demographic crisis and too many old people to take care of them, there could be millions of elderly dying right now, and there's no way for you to know if they've suppressed the figures or not.

The HCRs don't want to pay people's pensions. They want you to wageslave and then die. They want young, fresh, able-bodied meat for that purpose. That's what this is ultimately about. All of the people who you think of as enemies? The likes of Putin, Biden, Xi Jinping, Boris Johnson, Scott Morrison, and Justin Trudeau? These people all shake hands and laugh at you behind closed doors. They are actively contemptuous of all of us, and scheming of ways to thin the herd and rebalance demographics on behalf of their true masters. Everything else you're seeing is theater.

The coagulopathy of COVID-19 is brought on by the release of von Willebrand factor and the formation of antiphospholipid antibodies, among other things. This is due to oxidative stress in the blood vessels accompanied by EC activation and sloughing. To put it in layman's terms, all the caulking is falling off the inside of these people's blood vessels, leading to pulmonary angioedema and sepsis. The clots are from the body desperately trying to patch the holes back up. In the case of COVID-19, it's not so much "clotting", like one or two or a dozen large clots, as it is the entire bloodstream thickening and becoming syrup. This process is resistant to blood thinners like heparin and tPA, and going too far with those can cause fatal hemorrhages.

I'd say that the key thing is to restore endothelial health and prevent EC activation as much as possible. Tocilizumab and infliximab can reduce IL-6 and TNF-a, but preventing the activation of the transcription factors that make those in the first place could be helpful.

APPA, or Apocynin and Paeonol, is being investigated as a drug formulation for osteoarthritis.

https://pubmed.ncbi.nlm.nih.gov/32383062/

Quote
Neutrophils are key players in the pathophysiological process underlying inflammatory conditions not only by release of tissue-damaging cytotoxic enzymes, reactive oxygen species (ROS) but also by secretion of important immunomodulatory chemokines and cytokines. Here, we report the effects of the novel agent APPA, undergoing formal clinical development for treatment of osteoarthritis, and its constituent components, apocynin (AP) and paeonol (PA) on a number of neutrophil functions, including effects on TNFα- expression and signalling. Neutrophils were treated with APPA (10-1000 µg/mL) prior to the measurement of cell functions, including ROS production, chemotaxis, apoptosis and surface receptor expression. Expression levels of several key genes and proteins were measured after incubation with APPA and the chromatin re-modelling agent, R848. APPA did not significantly affect phagocytosis, bacterial killing or expression of surface receptors, while chemotactic migration was affected only at the highest concentrations. However, APPA down-regulated neutrophil degranulation and ROS levels, and decreased the formation of neutrophil extracellular traps. APPA also decreased cytokine-stimulated gene expression, inhibiting both TNFα- and GM-CSF-induced cell signalling. APPA was as effective as infliximab in down-regulating chemokine and IL-6 expression following incubation with R848. Whilst APPA does not interfere with neutrophil host defence against infections, it does inhibit neutrophil degranulation, and cytokine-driven signalling pathways (e.g. autocrine signalling and NF-κB activation), processes that are associated with inflammation. These observations may explain the mechanisms by which APPA exerts anti-inflammatory effects and suggests a potential therapeutic role in inflammatory diseases in which neutrophils and TNFα signalling are important in pathology, such as rheumatoid arthritis.

Apocynin is found in kutki powder (ground-up picrorhiza kurroa root), and paeonol comes from peony root bark (p. suffruticosa).

Normally, I would not suggest herbal medicine for a virus as nasty as SARS-CoV-2, but there are many benefits of plant polyphenols in dealing with oxidative stress, and the triggers of inflammatory cytokines are often set off by oxidative processes interacting with the MAPK pathway, and, well, what we're really talking about here is acute inflammation that mimics rheumatic diseases, but occurs primarily in the vasculature.

Given that APPA shows the potential to reduce ROS release from neutrophils and prevent IL-6 and TNF-a release, and also given that COVID-19 involves a great deal of neutrophil degranulation/NETosis, oxidative stress, and IL-6 and TNF-a release, the science behind this is entirely logical. Granted, the concentrations found in plant roots are much, much lower than what you'd get if they isolated and purified them.
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