...
Every "donor" likely has its own motives and unless someone brags about it, we won't know what those are. Collective stupidity on X is another, uhm, topic. Another reason not to visit this island of (a)social shit.
Are the Bitcoins in this address unspendable and as such, lost to the world?
I think I already wrote about it in this (or maybe another thread). If we assume the private key for the known public key of the Genesis block still exists (nobody knows this, except for Satoshi), then all coins that have been sent to the Genesis block are technically spendable, except for the initial coinbase amount of 50
BTC which are unspendable because they aren't in the UTXO set.
My gutt feeling is just that Satoshi won't ever move any of those coins. Why? Well, because!

If I'm right with my gutt feeling, then any donation to the Genesis block is simply frozen until some breakthrough in math or some imaginary quantum computer breaks DLP and finds the private key by reversing the unique relation private key -> public key in finite time and amount of energy.
TL;DR
At present and foreseeable future nobody can and Satoshi won't move any of those coins. Technically they're not lost, practically they're frozen and unmovable. Coins that won't move, bloat the UTXO set. I guess there's worse than that.
...

I could throw some sats at block #0 too, but I won't. See no point in doing so.
...
Here's a screenshot from my watch-only wallet in Core sorted in descending order of largest "donations". The almost 27
BTC are truely "obscene" because they were sent in 2024!

...
If that's actually the case, I'd laugh my ass off. I've already a big grin in my face. Hilarious!
...
We don't know if those coins have to be considered as "lost".