No matter what so called "safest" wallet you're using, it should be paired with a safe device where you installed the wallet and of course, use it with responsibility or else something malicious will get your funds.
^ true, the most vital is the security of your network and laptop/computer. because threat usually enter from this vulnerability.
Hardware wallets are safer comparing to many others. Trezor and ledger. I use trezor. it doesn't support too many things like neo. But trezor is more user friendly and easy to use for a beginner.
^ Trezor and Ledger are very safe but have big risks, that is;
missing. because of its small shape so the owner has a tendency to forget if it is not placed in a place that is easy to remember.