Look at what has happened to hollywood since people started pirating the films constantly. There has hardly been an original film made there in the last 10 years!
Actually all the evidence about Hollywood shows that they are making more money than *ever before* (and most of the new films make that money within their first week now). There is a good TED Talk about this specific thing (I suggest watching it).
Also if you look at the film Interstellar it was not only a great film but involved some incredible R&D with the some of the key special effects being actually based upon correctly modelled physics.
The film will have been "pirated" all over the place already but they have already made their profits (so it really isn't relevant to their "bottom line").
Basically Hollywood has "solved" the problem with the idea of getting people to go to cinemas in particular (and wanting to see the "new release" there).
So although they keep "crying poor" they have worked out how to re-invent themselves in the 21st century (maybe big Pharma needs some lessons).