The match will determine whether Dortmund can still put pressure on Bayern Munich at the top of the table or let them sit comfortably, because the 3 points they can get against Bayern this week will automatically narrow the gap between them, but honestly even if they beat Bayern, the Bundesliga throne will most likely remain Bayern Munich at the end of the season, they are unstoppable.
However, given that Dortmund has failed in the UCL, this Bundesliga match might motivate them to continue making life difficult for Bayern Munich.
I doubt that after a grueling 120-minute game with Atalanta, Dortmund will have the strength to fight against a fresh Bayern. I'd rather believe that Bayern will score their usual 3-4 goals and the title race will no longer even be mentioned when talking about the Bundesliga. This will likely be a spectacular game, but in terms of tournament play, the games between Bayer, Stuttgart, and Leipzig will be more interesting. Bayer and Stuttgart are lucky to play at home after their Europa League games.