BTCMILLIONAIRE
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February 17, 2019, 04:36:58 PM |
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Actually age is degradation in the cells.
When you are younger they regenerate fine.
The challenge is to halt or reverse this degradation.
I believe there are current successful studies, stimulating the repair function back into order.
That's the whole "senescent cells" approach. Basically tries to kill senescent cells (cells that stop dividing) which accumulate with age. Human trials are starting this year by the way.
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bitserve
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February 17, 2019, 04:39:37 PM |
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Where are they selling "live forever upgrades" these days? Cause I see the world's wealthiest still turn into fossils and die. You'd think they'd buy it if available ... Life extending technology will eventually be invented. But not for the next 100 years. I would consider looking up a digest of the progress on life extension at least every other year, starting now. There's a decent amount of buzz going on there, comparable to Bitcoin 10 years ago. The current "cutting edge" claims are a 50/50 chance for catching up to the aging escape velocity by 2040-50, and claims for minor rejuvenation (adding less years than you'd need to halt/reverse aging) by 2030ish. Cryopreservation is also becoming significantly cheaper, so that could be an option for people too old to make it to even 2050. Around the next rally a fraction of a Bitcoin could be enough for the cryopreservation part, and with a sensible portfolio you could "unfreeze" filthy rich whenever the technology is there. tl;dr We're virtually around the corner (relatively speaking). So anyone who feels like potentially being able to choose their point of death should do some digging. Any new research about body transplants of genetical clones? THAT would be the way to go. Maybe something already achieved in animals/rats? There was a plan for the first ever human head transplant a year or so ago. But I don't think anything came from that, so I'm not sure if that actually happened or got delayed. There are a few different paths to this problem. One would be to continuously repair the effects of aging. And the other would be to stop aging entirely. The ways to achieve either of these include replacing the human body entirely (with a cloned biological body, artificial physical body, digital/mind upload), repairing the human body by reversing the effects of aging, or halting the effects of aging altogether. There is progress happening on all of these fronts. We have cloned organs, cloned animals. [Potential biological body replacements] Artificial limbs that can be mind controlled with actual sensorial feedback. [Artificial body replacements] Mind control of artificial and digital objects. [Mind upload] Different approaches with cells (senescent cells and senolytic drugs), genes (Crispr), blood shown to reverse some effects of aging in rats. [Reversing/halting the effects on a biological level] As time goes by these will become more sophisticated and probably result in multi-lateral approaches to dealing with aging. So far they're baby steps, but they're bound to compound exponentially over time. With more progress there comes more funding, with more funding more progress. Same old feedback loop. The problem with the full body transplant is mainly making the neural reconnections. Once that solved most the way ahead is clear. Nanotech, microsurgery, automation, etc... advances in those fields maybe could lead to that. But I thought maybe some "crude" experiment with moderate success could have already been made in animals. It seems not. Digital mind/upload is another way I don't think is viable as a life extending alternative. I mean, you could end with a similar person but it would just be a copy, not me, not my conscience of being me.... if it was even possible anyways. Reversing/halting the effects of aging also sound like sci-fi at this time. More so the reversing part of it. It's the full body transplant the only thing I could consider viable even if the tech to carry it is still way far.
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bitserve
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February 17, 2019, 04:42:32 PM |
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Where are they selling "live forever upgrades" these days? Cause I see the world's wealthiest still turn into fossils and die. You'd think they'd buy it if available ... Life extending technology will eventually be invented. But not for the next 100 years. I would consider looking up a digest of the progress on life extension at least every other year, starting now. There's a decent amount of buzz going on there, comparable to Bitcoin 10 years ago. The current "cutting edge" claims are a 50/50 chance for catching up to the aging escape velocity by 2040-50, and claims for minor rejuvenation (adding less years than you'd need to halt/reverse aging) by 2030ish. Cryopreservation is also becoming significantly cheaper, so that could be an option for people too old to make it to even 2050. Around the next rally a fraction of a Bitcoin could be enough for the cryopreservation part, and with a sensible portfolio you could "unfreeze" filthy rich whenever the technology is there. tl;dr We're virtually around the corner (relatively speaking). So anyone who feels like potentially being able to choose their point of death should do some digging. It is not physically possible to freeze humans and revive them at a later date. That is fantasy. What qualifications do you have to make such claim? I've found no evidence for it. Unless you'd like to revise your statement to "you can't currently revive frozen humans". Water turns into ice when it freezes. Yes that is all there is to be said on the topic. Don't even bother. Non-argument. Assumes that damage won't be repairable in the future based on incomplete knowledge of pretty much everything. The damage is too much. We are talking about irreparable "data-loss" damage here. You can't repair what is already gone. In the future, you could probably farm a genetical clone from the available DNA but the brain is fucked up.
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Ibian
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February 17, 2019, 04:43:15 PM |
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Have any of you been under the gentle care of the medical system in the past few years, incidentally?
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Indamuck
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February 17, 2019, 04:43:31 PM |
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The only thing that really extends life a significant amount is fasting. You can take any living creature and restrict the amount of calories it intakes and it will live much longer.
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Last of the V8s
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February 17, 2019, 04:45:49 PM |
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Oh Homer you poor old sausage. Very sad to hear that. Stay with us and we will keep you busy. But what a fucking thing.
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xhomerx10
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February 17, 2019, 04:47:09 PM |
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The only thing that really extends life a significant amount is fasting. You can take any living creature and restrict the amount of calories it intakes and it will live much longer.
I read about this recently. Apparently fasting gives the body a boost in immune response and increase in growth hormone production.
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jojo69
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February 17, 2019, 04:47:27 PM |
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Cheeky bastards have got me in a guillotine mood. Stand aside Maximilien, let me show you how it's fucking done.
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wachtwoord
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February 17, 2019, 04:48:15 PM |
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Where are they selling "live forever upgrades" these days? Cause I see the world's wealthiest still turn into fossils and die. You'd think they'd buy it if available ... Life extending technology will eventually be invented. But not for the next 100 years. I would consider looking up a digest of the progress on life extension at least every other year, starting now. There's a decent amount of buzz going on there, comparable to Bitcoin 10 years ago. The current "cutting edge" claims are a 50/50 chance for catching up to the aging escape velocity by 2040-50, and claims for minor rejuvenation (adding less years than you'd need to halt/reverse aging) by 2030ish. Cryopreservation is also becoming significantly cheaper, so that could be an option for people too old to make it to even 2050. Around the next rally a fraction of a Bitcoin could be enough for the cryopreservation part, and with a sensible portfolio you could "unfreeze" filthy rich whenever the technology is there. tl;dr We're virtually around the corner (relatively speaking). So anyone who feels like potentially being able to choose their point of death should do some digging. I'm really interested but I think the "best" thing so far is Rapamycine and that is highly experimental, only tested on mice and its unknown why it works. I've been looking at this at least yearly for a decade and its a strong desire of mine as I consider human lives crazy short (plus I want to see the future, living is the only time machine likely feasible in our universe). If you have better/more info available I'm very interested. Links are perfectly fine too. Thanks! ![Smiley](https://bitcointalk.org/Smileys/default/smiley.gif)
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BTCMILLIONAIRE
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February 17, 2019, 04:48:49 PM |
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The problem with the full body transplant is mainly making the neural reconnections. Once that solved most the way ahead is clear. Nanotech, microsurgery, automation, etc... advances in those fields maybe could lead to that. But I thought maybe some "crude" experiment with moderate success could have already been made in animals. It seems not.
Digital mind/upload is another way I don't think is viable as a life extending alternative. I mean, you could end with a similar person but it would just be a copy, not me, not my conscience of being me.... if it was even possible anyways.
Reversing/halting the effects of aging also sound like sci-fi at this time. More so the reversing part of it.
It's the full body transplant the only thing I could consider viable even if the tech to carry it is still way far.
There are artificial limbs (arms with hands and fingers) that were successfully attached to amputees. They were connected to the nerves of the patient, which was then able to use the arm as his own while also being able to feel things with it. So we already have this demonstrated not in animals, but in humans. The reason this is moving so slowly is because you can't just walk around attaching heads to bodies.I don't see why the digital presence should not be you, as long as the connection is established properly (rather than just copying your memories onto a computer). But there is a simple solution to this problem. You create an interface with which you are simultaneously aware of your physical body and digital presence. Add a function that allows you to temporarily enable and disable either presence while keeping your consciousness. That way you can test for yourself if the digital version of you is still "you". Depending on the results of this you can choose yourself what you want to do. May sound sci-fi, but is not. It's reality and has been demonstrated in rats and more primitive animals. Life-spans have been extended quite significantly in those and clinical human trials started this year. The problem with human trials is that, well, it kind of takes a lifetime to get one data point.Full body transplant is the one that seems the most bothersome to me. At least for life extension purposes. This seems more like a "get a resilient body that won't get smashed in a car accident" kind of thing. It'd also probably be quite cumbersome to shit billions and billions and billions of human bodies for replacements.
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mindrust
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February 17, 2019, 04:51:15 PM |
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It is your memory which makes you "you". So as long as your memory lives, you live. Whether it lives on a computer or on a living body doesn't matter.
As long as you still remember certain events happened in your life, that's you.
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xhomerx10
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February 17, 2019, 04:52:29 PM |
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Oh Homer you poor old sausage. Very sad to hear that. Stay with us and we will keep you busy. But what a fucking thing.
Thanks V8 ![Wink](https://bitcointalk.org/Smileys/default/wink.gif) Fortunately, I didn't quit my day-job (well I work shift... but you know what I mean) and soon I will qualify for discount meals at the local senior center. Wednesday is roast beef dinner day - currently only CAD $5.84 with a beverage (non-alcoholic).
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jojo69
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February 17, 2019, 04:53:06 PM |
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It'd also probably be quite cumbersome to shit billions and billions and billions of human bodies for replacements.
I think I may have stumbled on a ready source of headless bodies...see above.
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BTCMILLIONAIRE
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February 17, 2019, 04:53:53 PM |
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The damage is too much. We are talking about irreparable "data-loss" damage here. You can't repair what is already gone. In the future, you could probably farm a genetical clone from the available DNA but the brain is fucked up.
With the information argument there's at bare minimum the option of restoring a human with impairments, then fixing the damage that stops them from acting human. Worst case scenario would be total (but probably partial) memory loss. Which would still potentially be preferable to some to certain death. And I'm not convinced whatsoever that any of the damage is permanently irreversible. We run data compression all the time. In reverse that means that you don't need full information to restore everything that's relevant.
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wachtwoord
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February 17, 2019, 04:54:18 PM |
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It'd also probably be quite cumbersome to shit billions and billions and billions of human bodies for replacements.
Billions? For what reason do you believe billions can afford this at any time in the next millennia. It will only be for the lucky few if available at all.
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gentlemand
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February 17, 2019, 04:55:41 PM |
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The only thing that really extends life a significant amount is fasting. You can take any living creature and restrict the amount of calories it intakes and it will live much longer.
I am solely interested in things that extend youth and middle age - which would be tricky without a black hole- not the utter horror and drudgery that comes after that. I'd rather be fat and dead than stringing out another 20 years of staring into the abyss on my bony buttocks.
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bitserve
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February 17, 2019, 04:57:19 PM |
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The problem with the full body transplant is mainly making the neural reconnections. Once that solved most the way ahead is clear. Nanotech, microsurgery, automation, etc... advances in those fields maybe could lead to that. But I thought maybe some "crude" experiment with moderate success could have already been made in animals. It seems not.
Digital mind/upload is another way I don't think is viable as a life extending alternative. I mean, you could end with a similar person but it would just be a copy, not me, not my conscience of being me.... if it was even possible anyways.
Reversing/halting the effects of aging also sound like sci-fi at this time. More so the reversing part of it.
It's the full body transplant the only thing I could consider viable even if the tech to carry it is still way far.
There are artificial limbs (arms with hands and fingers) that were successfully attached to amputees. They were connected to the nerves of the patient, which was then able to use the arm as his own while also being able to feel things with it. So we already have this demonstrated not in animals, but in humans. The reason this is moving so slowly is because you can't just walk around attaching heads to bodies.I don't see why the digital presence should not be you, as long as the connection is established properly (rather than just copying your memories onto a computer). But there is a simple solution to this problem. You create an interface with which you are simultaneously aware of your physical body and digital presence. Add a function that allows you to temporarily enable and disable either presence while keeping your consciousness. That way you can test for yourself if the digital version of you is still "you". Depending on the results of this you can choose yourself what you want to do. May sound sci-fi, but is not. It's reality and has been demonstrated in rats and more primitive animals. Life-spans have been extended quite significantly in those and clinical human trials started this year. The problem with human trials is that, well, it kind of takes a lifetime to get one data point.Full body transplant is the one that seems the most bothersome to me. At least for life extension purposes. This seems more like a "get a resilient body that won't get smashed in a car accident" kind of thing. It'd also probably be quite cumbersome to shit billions and billions and billions of human bodies for replacements. But when I talk about full body transplant I mean what some people incorrectly call a brain transplant. The amount of neural reconnections needed for that surgery is... well... very far off of connecting a few thick nerves for a limb. Also, for that to function properly it would need to be an exact genetical clone. Otherwise the brain would probably don't know how to properly "operate" the new alien body. I am speculating of course. About the digital presence.... well, I am sure it would behave exactly like me. But it won't be me. Not my conscience self. If you take the code of two programs and copy them. Then run each instance... each instance behaves the same, but it is not the SAME. It's hard for me to explain this in english.
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El duderino_
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February 17, 2019, 04:59:02 PM |
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Just goes to show that if you're gonna buy something with Bitcoin, make it count, so you'll have no regrets years later. ![Cheesy](https://bitcointalk.org/Smileys/default/cheesy.gif) indeed, i try to use BTC from time to time to make payments, but never from the HODL/cold storage stash *thats a "hole" with an only ingoing and strictly no outgoings whatsoever* but if one hodl and just buy some extra BTC to use for payments why not its only good ![Cheesy](https://bitcointalk.org/Smileys/default/cheesy.gif)
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Last of the V8s
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February 17, 2019, 05:03:19 PM |
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Oh Homer you poor old sausage. Very sad to hear that. Stay with us and we will keep you busy. But what a fucking thing.
Thanks V8 ![Wink](https://bitcointalk.org/Smileys/default/wink.gif) Fortunately, I didn't quit my day-job (well I work shift... but you know what I mean) and soon I will qualify for discount meals at the local senior center. Wednesday is roast beef dinner day - currently only CAD $5.84 with a beverage (non-alcoholic). Seems xclnt value. Remember to liberate the sachets of horseradish sauce etc for spicing up noodle soups. Still can't quite believe the mayor just ran off with all your money, but there's no accounting for folk.
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BTCMILLIONAIRE
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February 17, 2019, 05:03:40 PM |
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It is your memory which makes you "you". So as long as your memory lives, you live. Whether it lives on a computer or on a living body doesn't matter.
As long as you still remember certain events happened in your life, that's you.
I disagree. You precede your memories. Without you being there first there is no you to have memories. The question is then whether or not you are the substrate that holds the memories. And in that case people run into a problem about putting their memories on a "different" computer (which my previous post shows how to solve in the future). I'm really interested but I think the "best" thing so far is Rapamycine and that is highly experimental, only tested on mice and its unknown why it works. I've been looking at this at least yearly for a decade and its a strong desire of mine as I consider human lives crazy short (plus I want to see the future, living is the only time machine likely feasible in our universe). If you have better/more info available I'm very interested. Links are perfectly fine too. Thanks! ![Smiley](https://bitcointalk.org/Smileys/default/smiley.gif) Not really sure about any links since I haven't checked in for a while. But you can run any of the keywords into Google and find plenty of sources. There are some serious researchers in Cambridge, Harvard and similar places these days. The main research institute for aging appears to be SENS by the way. And with some of the keywords I've mentioned they're not directly being pursued for aging, but if you look at them you'll see that they offer themselves to that in the future.
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