Pretty sure when two instances was tested, it's worse pool side. It just looks better locally when you add up both outputs.
Can i combine different cards in one rig for example gtx 1070 with gtx 1060 or 1050ti?
sure you can even do it with amd plus nvidia, with the same gen it's even more easy they use the same drivers so no problem there
I would definitely not intermingle cards on rigs. Heard plenty of horror stories about that, especially considering you usually have to run multiple miners at the same time. That's just asking for problems.
Theoretical is quite a bit different then being put into use here.